SK&F96365对大鼠肝缺血再灌注损伤后Kupffer细胞钙池操纵的钙通道电流的影响
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姜 楠, 张宗明, 郭金星, 刘 亮, 张 驰,
Kupffer细胞;肝缺血再灌注损伤;钙池操纵的钙通道电流;钙通道阻滞剂姜楠,张宗明,郭金星,刘亮,张驰,张嫣璐,张子超.SK&F96365对大鼠肝缺血再灌注损伤后Kupffer细胞钙池操纵的
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姜楠, 刘亮, 张驰, 张嫣璐, 张子超, 同济大学附属同济医院普外科 上海市 200065
张宗明, 郭金星, 清华大学第一附属医院消化中心普外科 北京市 100016
姜楠, 2003年硕士研究生, 同济大学附属同济医院普外一科, 主要从事细胞离子通道与肝胆外科疾病的研究.国家自然科学基金资助项目, No. 30270532
教育部跨世纪优秀人才培养计划基金资助项目, 教技函(2002) 48号
上海市教委曙光计划基金资助项目, No. 02SG20
通讯作者: 张宗明, 100016, 北京市朝阳区酒仙桥一街坊6号, 清华大学第一附属医院消化中心普外科. zhangzongming@mail.tsinghua.edu.cn
电话: 010-64372362 传真: 010-64361322
收稿日期: 2006-04-24 接受日期: 2006-06-30
Effect of SK&F96365 on store-operated Ca2+ channel currents of Kupffer cells after hepatic ischemia and reperfusion injury in rats
Nan Jiang, Zong-Ming Zhang, Jin-Xing Guo, Liang Liu, Chi Zhang, Yan-Lu Zhang, Zi-Chao Zhang
Nan Jiang, Liang Liu, Chi Zhang, Yan-Lu Zhang, Zi-Chao Zhang, Department of the General Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China
Zong-Ming Zhang, Jin-Xing Guo, Department of General Surgery, Digestive Medical Center, the First Hospital of Tsinghua University, Beijing 100016, China
Supported byNational Natural Science Foundation of China, No. 30270532; Trans-Century Training Program Foundation for the Excellent Talents from the Ministry of Education of China, Official Letter No. 2002-48; Shuguang Program of Shanghai Education Committee, No. 02SG20
Correspondence to: Professor Zong-Ming Zhang, Department of General Surgery, Digestive Medical Center, the First Hospital of Tsinghua University, Beijing 100016, China. zhangzongming@mail.tsinghua.edu.cn
Received: 2006-04-24 Accepted: 2006-06-30
AbstractAIM:To investigate the changes of store-operated calcium channel currents (ISOC) after hepatic ischemia and reperfusion (I/R) injury in isolated Kupffer cells of rats, and the effects of Ca2+ channel blockers, SK&F96365, on ISOC of Kupffer cells.
METHODS: The SD rat model of hepatic I/R injury was established ......
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