[摘要] 目的 观察血小板去除术联合羟基脲、干扰素-α治疗原发性血小板增多症(PT)的疗效。方法 对22例PT患者采用血小板去除术1~4次后，立即给予羟基脲和干扰素-α治疗。结果 血小板去除术后，患者外周血中血小板计数明显下降，临床症状好转，再经羟基脲、干扰素-α联合治疗，所有患者病情均得到明显改善。结论 血小板去除术联合羟基脲、干扰素-α治疗PT有显著疗效。

    [关键词] 血小板增多，出血性；血小板去除术；羟基脲；干扰素-α

    Treatment of primary thrombocythemia with platelet separation plus medication:Experence of 22 cases

    XU Xu,LI Xiao-bin,XIE Zhao-xia.Department of Hematology,Hospital 331 of Zhuzhou,Zhuzhou 412002,China

    [Abstract] Objective To observe the clinical effects of platelet separation plus hydroxyurea, INF-α on primary thrombocythemia(PT). Methods All patients were treated with platelet separation and hydroxyurea, INF-α in turn.Results After platelet separation, the platelet count of patients decreased significantly and the symptoms referable to thrombocythemia were improved. Then, all cases were treated with hydroxyurea, INF-α and got obviously amelioration finally. Conclusion The method of platelet separation plus hydroxyurea and INF-α have significant effects on PT. ......