Relationship between p53 codon 72 polymorphism and liability of squamous cervical cancer in Han population of Shaanxi province: Caseª²control study

    LI Jun, ZHENG Quanª²Qing, WANG Ping

    Xi¬ðan Center for Disease Control and Prevention, Xi¬ðan 710054, China, Department of Epidemiology and Statistics, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China, Department of Gynecologic Oncology, Tumor Hospital of Shaanxi Province, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To explore the relationship between genetic polymorphism of p53 codon 72 and the risk of squamous cervical cancer. METHODS: A caseª²control study was conducted in Han population of Shaanxi province, involving 33 women with squamous cervical carcinoma as experimental group, and 51 same ethical normal women as control group. DNA extracted from peripheral blood samples and pathologic tissues were examined by PCR with allele specific primers. RESULTS: The rates of arginine (Arg) and proline (Pro) homozygosity and Arg/Pro heterozygosity were 33%, 15% and 52% in experimental group, respectively, 22%, 18% and 61% in control group, respectively. The A of Pro/Pro or Arg/Pro genotype was 1.80 (95%CI=0.37ª²8.97) compared with Arg/Arg genotype. The A of Pro allele compared with Arg allele was 1.34 (95%CI=0.68ª²2.62) . Chiª²square analysis showed no significant differences between the 2 groups (P>0.05). CONCLUSION: Polymorphism at codon 72 of p53 gene may be not associated with an increased susceptibility to squamous cervical cancer. ......