腹腔镜；组织型纤溶酶原激活物(tPA)；纤溶酶原激活物抑制

血清tPA和PAI1水平在腹腔镜手术中的临床意义

http://www.100md.com 《腹腔镜外科杂志》 2006年第4期

腹腔镜；组织型纤溶酶原激活物(tPA)；纤溶酶原激活物抑制物1(PAI1),,腹腔镜；组织型纤溶酶原激活物(tPA)；纤溶酶原激活物抑制物1(PAI1),血清tPA和PAI1水平

     【摘要】 目的：探讨腹腔镜与开腹手术中血浆纤维蛋白溶酶的变化。方法：在腹腔镜与开腹手术前、术后8h分别测量血浆中组织型纤溶酶原激活物(Tissuetype plasminogen activator,tPA),纤溶酶原激活物抑制物1(Plasminogen activator inhibitor type1,PAI1)浓度。结果：血浆tPA浓度在腹腔镜手术和传统腹部手术两组病例术后均下降，但在传统腹部手术组下降更显著(P<0.05),而血浆PAI1浓度在腹腔镜手术和传统腹部手术两组病例术后均升高，但在传统腹部手术组升高更显著(P<0.05)。结论：本次临床研究结果表明：腹腔镜手术组术前、术后血浆中tPA、PAI1浓度的变化小于传统腹部手术组，腹腔镜手术组引起腹腔粘连严重程度也低于传统腹部手术组。

     【关键词】 腹腔镜；组织型纤溶酶原激活物(tPA)；纤溶酶原激活物抑制物1(PAI1)

    The expression of level of tissuetype plasminogen activator (tPA) and plasminogen activator inhibitor type1 (PAI1) in peptone plasma duing laparoscopic surgery HU Xingqian,WANG Tong,ZHOU Xiong,et al.The First Hospital of Wuxi,Wuxi 214002,China

    【Abstract】 Objective:To investigate fibrinolytic changes in peptone plasma during laparoscopic and conventional abdominal surgery.Methods:In laparotomy peptone plasma were taken before opening of the abdomen and 8 hours after closure.In laparoscopy peptone plasma were taken before carbo dioxide insufflation and eight hours after exsufflation.Peptone plasma concentration of tissuetype plasminogen activator (tPA) and plasminogen activator inhibitor type1 (PAI1) were assayed.Results:Both groups experienced postoperative decrease in concentration of tPA in peptone plasma,while more significant decrease was observed in the laparotomy group (P<0.05).Meanwhile,PAI1 concentration increased in both groups after surgery,but more significantly in the laparotomy group (P<0.05).Conclusions:These findings indicate less fibrinolytic changes in peptone plasma and less severity in postoperative introperitoneal adhesions after laparoscopic than after conventional abdominal surgery. ......

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