LU Jianª²Guo1, WANG Qing1, MA Qingª²Jiu1, NING Li1, FANG Qing2, CHU Yanª²Kui1, DU Xiª²Lin1, YANG Yuan1, LIN Chen2

    1Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China, 2State Key Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences£¬Beijing 100021, China

    ¡¾Abstract¡¿ AIM: To investigate the expression and significance of selenoprotein P in colon carcinoma tissues. METHODS: Samples were derived from 30 cases of colon carcinoma£¬and 30 corresponding normal colon tissues were used as controls. The expression of selenoprotein P in colon carcinoma tissues were investigated by immuohistochemical stain. RESULTS: The expression rate of selenoprotein P in colon carcinoma(60.0%) was significantly lower than that of their control normal tissues(80.0%, P<0.05). The expression rate of selenoprotein P in highª² and moderateª²differentiation cases(86.7%) was higher than that of lowerª²differentiation tissues(33.3%, P<0.05). The expression rate of selenoprotein P was 58.8% in Iª²II stage cases, and 61.5% in III stage cases(P>0.05). CONCLUSION: The expression which of selenoprotein P is low in colon carcinoma tissues, which is related with differentiation levels of colon carcinoma, but not with TNM stage of tumor. ......