XIAO Yin1, CHEN Chongª²Shang2, HUA Jun3, BAI Juan4, MA Yongª²Zhi1

    1Department of Pharmaceutics, Shaanxi Provincial Corps Hospital, Chinese People¬ðs Armed Police Forces, Xi¬ðan 710054, China, 2Xizhu Institute of Medical Product, Xi¬ðan 710054, China, 3Department of Pharmaceutics, PLA 154 Hospital, Xinyang 464000, China, 4Department of Pharmaceutics, PLA 537 Hospital, Baoji 721000, China

    ¡¾Abstract¡¿ AIM: To study the protective effects of WUJIASHUANGSHEN tablets (WJSST) on cells against radiation damage and chemical injury. METHODS: The radiation damage models in rats were induced by 60Co as the radiant substance. We counted the numbers of the peripheral blood leucocytes, medullary cells and the micronuleated cells and measured the content of DNA in thymocytes. The models of hypocytosis were induced by cyclophosphamide and the numbers of the leucocytes and thrombocytes were counted. RESULTS: When WJSST were administered after radiation damage by 60Co, the numbers of the leucocytes and medullary cells were obviously increased as compared with blank group and leucogen control group (P<0.01). The percentage of the micronuleated cells in the WJSST groups was markedly lower than that in model group (P<0.01). As to the content of DNA in the thymocytes, the WJSST groups were significantly higher than that in the model group (P<0.01). When WJSST were administered after chemical injury by cyclophosphamide, the numbers of the leucocytes and thrombocytes were markedly increased as compared with those of the blank group and control groups (P<0.01). CONCLUSION: WJSST have the protective effects against the radiation damage and chemical injury such as the increasing peripheral blood leucocytes and medullary cells, the decreasing the number of micronucleated cells, the increasing the content of DNA in thrombocytes. ......