L精氨酸；牛磺酸；缺氧；缺氧性肺动脉高压____

L精氨酸和牛磺酸联合抗缺氧损伤及防治缺氧性肺动脉高压的研究

http://www.100md.com 《局解手术学杂志》 2006年第4期

L精氨酸；牛磺酸；缺氧；缺氧性肺动脉高压,,],L精氨酸；牛磺酸；缺氧；缺氧性肺动脉高压,[摘要],[关键词],1材料与方法,2

     [摘要] 目的研究L精氨酸、牛磺酸联合应用的抗缺氧损伤以及对缺氧性肺动脉高压(HPH)的防治效果。方法雄性Wistar大鼠40只，制作缺氧性HPH模型，随机分为平原对照组(C)、单纯缺氧组(H)、缺氧+L精氨酸组(Arg )、缺氧+牛磺酸组(Tau)、缺氧+牛磺酸+L精氨酸组(TA)，测定各组的肺动脉压(mPAP)、右心室肥大指数(RVHI)、血浆乳酸脱氢酶(LDH)、脂质过氧化产物丙二醛(MDA)、肺匀浆NO含量的变化。结果 H组与C组相比，mPAP高出约25 mmHg (P<001)，RVHI增加156倍(P<001)，血浆LDH活性增高101倍(P<001)，血浆MDA含量增加164(P<001)，而肺匀浆NO含量降低68%(P<001)。各治疗组与H组相比，mPAP均显著降低5 mmHg(P<005)，RVHI均显著降低20%(P<001)，血浆LDH活性显著降低(P<001)，其中TA组与Arg组比较有显著差异(P<001)，血浆MDA含量显著降低(P<001)，但各治疗组之间无显著性差异。肺匀浆NO含量在Tau组无显著性变化，在Arg和TA组显著回升(P<001)。结论 L精氨酸和牛磺酸具有抗缺氧损伤及防治肺动脉高压的效果，两者联用可进一步增加NO产生，减少乳酸脱氢酶的漏出，加强细胞保护作用。

     [关键词] L精氨酸；牛磺酸；缺氧；缺氧性肺动脉高压

    Protection against hypoxic injury and amelioration of hypobaric hypoxic pulmonary hypertension by treating with Larginine combined taurine in rats

    XU Shumin, ZHENG Lüzhen, LIU Fuyu, CHEN Li, WANG Peiyong (Department of Pathophysiology and High Altitude Physiology, Third Military Medical University, Chongqing 430038, China)

    Abstract: Objective Exposure to hypoxia induces hypoxic pulmonary hypertension (HPH), the effects of taurine (Tau) and Larginine (Arg), and their combination (TA) on prevention against HPH were investigated Methods Adult male Wistar rats were divided into two groups: sea level control group (C) and hypoxia group, and the hypoxia group was divided into three subgroups further, namely hypoxia control (H), Tau, Arg and TA group The therapy groups were given corresponding drugs every day orally After exposed for 2 weeks in a hypobaric chamber at simulated high altitude of 5 000 meters, the effects of the above drugs were evaluated Results The rats of H group developed remarkable HPH and right ventricle hypertrophy (RVH), with an elevated mean pulmonary artery pressure (mPAP) of about 25 mmHg above and the right ventricular hypertrophy index (RVHI) of 156 folds higher (P<001) The activity of lactic dehydrogenase (LDH) and level of malondialdehyde (MDA) in the plasma of H group were 101 and 164 folds higher than those of respective control groups (P<001), while the NO production in the lung tissue of H group was 68% lower than that of C group (P<001) The development of HPH and RVH was ameliorated in the groups with the above drugs administered respectively, with about 5 mmHg of mPAP below (P<005), and RVHI about 20% lower than those of H group (P<001) The activity of LDH in each therapy group showed markedly decreases (P<001,TA vs Arg, P<001), and the levels of MDA also showed significant decreases (P<001) NO productions in the lung tissues resumed of Arg and TA groups (P<001) Conclusion The results suggest that taurine, Larginine and their combinaion exert cytoprotective effects on hypoxic injury, inhibit lipidperoxidation, mitigate hypoxic pulmonary hypertension and reduce right ventricle hypertrophy ......

百拇医药网 http://www.100md.com/html/DirDu/2006/09/20/17/76/33.htm

您现在查看是摘要页，全文长 10636 字符。