白介素-8、白介素-15在结肠癌患者结肠黏膜的表达及意义
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高 伟, 吴 瑜, 司雁菱
结肠癌;白介素-8;白介素-15;免疫组化高伟,吴瑜,司雁菱.白介素-8、白介素-15在结肠癌患者结肠黏膜的表达及意义. 世界华人消化杂志2006;14(28)2806-2809̳
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高伟, 司雁菱, 唐山工人医院消化科 河北省唐山市 063000
吴瑜, 唐山工人医院病理实验中心 河北省唐山市 063000
通讯作者: 高伟, 063000, 河北省唐山市, 唐山工人医院消化科. gw222001@yahoo.com.cn
电话: 0315-3722233
收稿日期: 2006-07-02 接受日期: 2006-07-31
Expression and significances of interleukin-8 and interleukin-15 in colonic mucosa of colon cancer patients
Wei Gao, Yu Wu, Yan-Ling Si
Wei Gao, Yan-Ling Si, Department of Gastroenterology, Worker’s Hospital, Tangshan 063000, Hebei Province, China
Yu Wu, Central Laboratory of Pathology, Worker’s Hospital, Tangshan 063000, Hebei Province, China
Correspondence to: Wei Gao, Department of Gastroenterology, Worker’s Hospital, Tangshan 063000, Hebei Province, China. gw222001@yahoo.com.cn
Received: 2006-07-02Accepted: 2006-07-31
Abstract
AIM:To investigate the expression of interleukin-8 (IL-8) and IL-15 in colonic mucosa from colon cancer patients and study their relationships with colon cancer.
METHODS: Immunohistochemical technique was used to detect the expression of IL-8 and IL-15 in 66 patients with colon cancer.
RESULTS: The positive rates of IL-8 and IL-15 were 66.7% (44/66) and 60.6% (40/66), respectively. Significant correlations existed between expression of IL-8, IL-15 and the following factors: clinical stages (IL-8: r = 0.437, P = 0.006; IL-15: r = 0.317, P = 0.014), invasive depth (IL-8: r = 0.332, P = 0.003; IL-15: r = 0.312, P = 0.015), regional lymph node metastasis (IL-8: r = 0.316, P = 0.042; IL-15: r = 0.236, P = 0.017), histologic grades (IL-8: r = 0.826, P = 0.0001; IL-15: r = 0.368, P = 0.001).
CONCLUSION: Detection of IL-8 and IL-15 expression is helpful in assessing the malignant degrees of colon cancer ......
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