肠毒素大肠杆菌攻毒小鼠模型的建立以及疫苗候选株保护效果的评价
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王志斌, 姜普林, 曾年华, 李淑琴, 王令春,
幽门螺杆菌;非甾体类消炎药;阿司匹林;塞莱昔布马慧霞,王蔚虹,胡伏莲,李江.阿司匹林和塞莱昔布对幽门螺杆菌的体外影响. 世界华人消化杂志2006;14(28)2747-2752,肠毒素大肠
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张兆山, 李淑琴, 王令春, 北京生物工程研究所 北京市 100071
王志斌, 姜普林, 曾年华, 广州军区疾病预防控制中心 广东省广州市 510507
李燕, 熊仕秋, 中山大学基础医学院 广东省广州市510089
王志斌, 1995年毕业于同济医科大学, 学位学士, 助理研究员, 主要从事流行病学研究.国家高技术研究发展计划资助项目(863计划), No. 2004AA215212
通讯作者: 张兆山, 100071, 北京市丰台区东大街20号, 北京生物工程研究所. zhangzs@nic.bmi.ac.cn
电话: 010-66948834 传真: 010-63833521
收稿日期: 2006-07-25 接受日期: 2006-08-10
Establishment of mice models following intranasal challenge with enterotoxigenic Escherichia coli strains and evaluation of protective effect following intranasal immunization with vaccine candidates
Zhi-Bin Wang, Pu-Lin Jiang, Nian-Hua Zeng, Shu-Qin Li, Ling-Chun Wang, Yan Li, Shi-Qiu Xiong , Zhao-Shan Zhang
Zhao-Shan Zhang, Shu-Qin Li, Ling-Chun Wang, Beijing Institute of Biotechnology, Beijing 100071, China
Zhi-Bin Wang, Pu-Lin Jiang, Nian-Hua Zeng, Center for Disease Prevention and Control, Guangzhou Military Command, Guangzhou 510507, Guangdong Province, China
Yan Li, Shi-Qiu Xiong, Pre-clinical College of Sun Yat-sen University, Guangzhou 510089, Guangdong Province, China
Supported by the Hi-Tech Research and Development Program (863 Program) of China, No. 2004AA215212
Correspondence to: Zhao-Shan Zhang, Beijing Institute of Biotechnology, 20 Dongda Street, Beijing 100071,China. zhangzs@nic.bmi.ac.cn
Received: 2006-07-25 Accepted: 2006-08-10
AbstractAIM:To investigate the possible effects of aspirin and celecoxib on the growth, virulence factors and outer membrane protein of H pylori.
METHODS: Two standard strains of H pylori were treated with a series concentration of aspirin or celecoxib (a specific inhibitor of cyclooxygenase 2) and were incubated in brucella broth under microaerobic condition for 24 and 48 h. The growth and urease activity were assessed by viable colony counting and spectrophotometry. After 48-hour treatment, the supernatants were incubated with Hela cells to estimate vacuolating cytotoxin activity ......
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