【摘要】 目的 观察补肾活血化痰法对拟血管性痴呆小鼠脑组织中NO、NOS及Glu的影响，进而探讨该法的作用机制。方法 复制脑部缺血再灌注拟血管性痴呆小鼠模型。术后15天检测各组小鼠脑组织内一氧化氮(NO)、一氧化氮合酶(NOS)、谷氨酸(Glu)的含量。结果 补肾活血化痰组小鼠脑组织内NO、NOS、Glu含量明显降低 (P<0.05～0.01)。结论 补肾活血化痰法能够抑制小鼠缺血脑组织中Glu的释放，进而降低NOS活性、减少NO合成，从而保护神经元，这可能是补肾活血化痰法治疗VD的部分作用机制。

    【关键词】 血管性痴呆；补肾活血化痰法；小鼠；NO；NOS；Glu

    Effects of kidney-invigorating，blood-promoting and phlegm-dissipating on No，NOS and Glu contents of brain tissues of mice with analog vascular dementia

    WANG Ya-li，HOU Xian-ming，NIU Bing，et al.TCM College，Hebei Medical University，Shijiazhuang 050091，China

    【Abstract】 Objective To observe the effects of kidney-invigorating，blood-promoting and phlegm-dissipating on NO，NOS and Glu contents of brain tissues of mice with analog vascular dementia，and to further explore the action mechamism of this method.Methods The model mice with analog vascular dementia were duplicated through ischemia-reperfusion in the brain.15 days after the operation ......