【摘要】 目的 观察富马酸并哌丙吡胺的镇痛及抗炎作用。方法 镇痛作用采用小鼠甩尾法和大白鼠扭体法。结果 小鼠甩尾法结果显示，富马酸并哌丙吡胺镇痛效应达97%。小鼠耳炎法结果，富马酸并哌丙吡胺组耳重(8.0±0.41)mg，对照组耳重(12.0±2.83)mg，富马酸并哌丙吡胺组比对照组耳重减少50%。大鼠棉球植入法，富马酸并哌丙吡胺组棉球重量为(35.58±9.79)mg，对照组为(47.0±12.15)mg，富马酸并哌丙吡胺组与对照组比棉球重量减少24%。结论 富马酸并哌丙吡胺具有强的镇痛作用及抗炎效果。

    【关键词】 富马酸并哌丙吡胺；镇痛；抗炎

    Experimental study on analgesic and anti-inflammatory effects of probne

    LI Juan，YU Xiao-li，YANG Hui-fen，et al.Department of Pharmacology，Institute of Basic Medicine，Chinese Academy of Medical Sciences，Beijing 100005，China

    【Abstract】 Objective To observe the analgesic and anti-inflammatory effects of probne. Methods Mouse tail-swinging test and rat writhing test were used to observe the analgesic effect of probne；anti-inflammatory action was investigated with mouse ear edema test and granuloma provoked by cotton-ball in rat. Results The analgesic effect of probne in mouse tail-swinging test is 97%；Probne inhibited the experimental inflammation in both tests ......