H pylori相关性胃溃疡、胃癌组织中VEGF和NF-κB的表达及意义
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袁禧先, 王凤荣, 薛鸿鹏, 姜 威
幽门螺杆菌;胃溃疡;胃癌;血管内皮生长因子;核转录因子κB,Hpylori相关性胃溃疡、胃癌组织中VEGF和NF-κB的表达及意义,袁禧先,王凤荣,姜威,薛鸿鹏,袁禧先,通讯作者:,Ex
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袁禧先, 王凤荣, 姜威, 佳木斯大学附属第一医院消化科 黑龙江省佳木斯市 154002
薛鸿鹏, 黑龙江省医院 黑龙江省哈尔滨市 150086
袁禧先, 1987年佳木斯医学院硕士, 主任医师、教授, 硕士生导师, 主要从事胃肠道肿瘤的免疫组化研究和胃肠道微生态研究.黑龙江省教育厅资金资助项目, No. 10541233
通讯作者: 袁禧先, 154002, 黑龙江省佳木斯市, 佳木斯大学附属第一医院消化科. yuanxx8862@163.com
收稿日期: 2006-06-28 接受日期: 2006-08-10
Expression of vascular endothelial growth factor and nuclear factor kappa B and their significances in Helicobacter pylori-associated gastric ulcer and gastric cancer
Xi-Xian Yuan, Feng-Rong Wang, Hong-Peng Xue, Wei Jiang
Xi-Xian Yuan, Feng-Rong Wang, Wei Jiang,Department of Digestive Diseases, the First Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
Hong-Peng Xue,Heilongjiang Provincial Hospital, Harbin 150086, Heilongjiang Province, China
Supported bythe Fund from Education Bureau of Heilongjiang Province, China, No. 10541233
Correspondence to:Dr. Xi-Xian Yuan, Department of Digestive Diseases, the First Affiliated Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China. yuanxx8862@163.com
Received:2006-06-28 Accepted:2006-08-10
Abstract
AIM: To probe the expression of vascular endothelial growth factor (VEGF), nuclear factor kappa B (NF-κB) in H pylori-associated gastric ulcer (GU) and gastric cancer (GC) tissues and their correlations, and further investigate the mechanism of H pylori-induced GU and GC.
METHODS: SABC immunohistochemical technique was used to detect the expression of H pylori, VEGF, and NF-κB in pathological samples of GU (n = 36) and GC (n = 52).
RESULTS: The incidence rate of GU existed significant difference between H pylori positive and negative group (78% vs 22%,P < 0.05). The expression of VEGF or NF-κΒ in H pylori positive GU tissues was markedly higher than that inH pylori negative ones (53.6% vs 12.5%, P < 0.05; 39.3% vs 0, P < 0 ......
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