YMDD耐药变异与HLA等位基因多态性的相关性
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张淑云, 李兴库, 董广璐, 仰曙芬, 谷鸿喜,
乙型肝炎病毒;慢性乙型肝炎;YMDD变异;人类白细胞抗原等位基因,张淑云,李兴库,仰曙芬,金茜,刘伟,杜博,卢滨,董广璐,谷鸿喜,李迪,张淑
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张淑云, 李兴库, 仰曙芬, 金茜, 刘伟, 杜博, 卢滨, 哈尔滨医科大学附属第二医院科研实验中心 黑龙江省哈尔滨市 150086
董广璐, 哈尔滨医科大学附属第二医院肿瘤放射治疗科 黑龙江省哈尔滨市 150086
谷鸿喜, 李迪, 哈尔滨医科大学微生物学教研室 黑龙江省哈尔滨市 150086
张淑云, 1993年哈尔滨医科大学硕士, 哈尔滨医科大学2003级博士生, 副主任医师, 主要从事临床分子病毒学研究和临床基因诊断工作.
黑龙江省自然科学基金资助项目, No. D0307
黑龙江省卫生厅课题基金资助项目, 2005-311
通讯作者: 董广璐, 150086, 哈尔滨市南岗区学府路246号, 哈尔滨医科大学附属第二医院肿瘤放射治疗科. dgl64@163.com
电话: 0451-86605742 传真: 0451-86688011
收稿日期: 2006-07-02 接受日期: 2006-08-10
Correlation of hepatitis B virus YMDD mutations with the polymorphism of HLA alleles in patients with chronic hepatitis B virus infection
Shu-Yun Zhang, Xing-Ku Li, Guang-Lu Dong, Shu-Feng Yang, Hong-Xi Gu, Di Li, Qian Jin, Wei Liu, Bo Du, Bin Lu
Shu-Yun Zhang, Xing-Ku Li, Shu-Feng Yang, Qian Jin, Wei Liu, Bo Du, Bin Lu,Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Guang-Lu Dong,Department of Tumor Radiotherapy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Hong-Xi Gu, Di Li,Department of Microbiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Supported bythe Natural Science Foundation of Heilongjiang Province, No. D0307, and the Fund from Health Department of Heilongjiang Province, No. 2005-311
Correspondence to:Guang-Lu Dong, Department of Tumor Radiotherapy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. dgl64@163.com
Received:2006-07-02 Accepted:2006-08-10
Abstract
AIM: To investigate the relationship between HBV YMDD mutations and the polymorphism of human leukocyte antigen (HLA) alleles in patients with chronic hepatitis B virus (HBV) infection.
METHODS: Fluorescent hybridization biprobe PCR and melting curve assay (FH-PCR-MC) was used to determine HBV YMDD mutations in serum specimens from 142 patients with chronic HBV infection ......
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