中药降肝隆联合抗病毒药长期治疗活动性肝炎肝硬变对其预后的影响
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文 睿, 王 坚, 陈 敏, 严 明
降肝隆;拉米夫定;阿德福韦酯;活动性肝硬变;乙型肝炎;YMDD变异;病死率;生存时间,文睿,王坚,陈敏,严明,文睿,通讯作者:
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文睿, 王坚, 陈敏, 东南大学附属南京市第二医院中西医结合科 江苏省南京市 210003
严明, 江苏省中医院中医内科 江苏省南京市 210003
文睿, 副主任中医师, 中华中医药学会学感染病专业委员会常委, 江苏省中医药感染病专业委员会委员, 从事中西医结合感染病临床医疗工作24年, 目前主要从事各类肝病的临床治疗.
通讯作者: 文睿, 210003, 江苏省南京市, 东南大学附属南京市第二医院中西医结合科. wenrui_51@qq.com
电话: 025-83607891
收稿日期: 2006-07-20 接受日期: 2006-08-10
Chinese medicine Jiangganlong combined with anti-virus medicine in long-term treatment of active liver cirrhosis and its effect on prognosis of patients
Rui Wen, Jian Wang, Min Chen, Ming Yan
Rui Wen, Jian Wang, Min Chen,Department of Integrated Chinese Medicine and Western Medicine, the Affiliated Nanjing Second Hospital of Southeast University, Nanjing 210003, Jiangsu Province, China
Ming Yan,Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210003, Jiangsu Province, China
Correspondence to:Rui Wen, Department of Integrated Chinese Medicine and Western Medicine, the Affiliated Nanjing Second Hospital of Southeast University, Nanjing 210003, Jiangsu Province, China. wenrui_51@qq.com
Received:2006-07-20 Accepted:2006-08-10
Abstract
AIM: To study the efficacy of Chinese medicine Jiangganlong combined with anti-virus medicine in the treatment of active liver cirrhosis (ALC).
METHODS: A total of 114 ALC patients were divided into treatment group and control group, named A and B, respectively. The patients in group A were treated with Jiangganlong and lamivudine (LAM). Jiangganlong decoction or pills were given a dose every three days, or 4.0 g (tid). LAM was administered 0.1 g per day. After the emergence of YMDD variations, adefovir (ADV) was added. LAM was stopped when HBV DNA YMDD variation became negative. The patients in group B received general and symptomatic treatment. The mean treatment therapeutic time was 36 months.
RESULTS: The rates of negative conversion for the serum HBV DNA were 75 ......
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