慢性萎缩性胃炎黏膜上皮中P53和C-erbB-2表达的临床意义
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赵 松, 付英梅, 赵 柏, 刘连新
慢性萎缩性胃炎;P53;C-erbB-2;胃癌;免疫组织化学赵松,付英梅,赵柏,刘连新.慢性萎缩性胃炎黏膜上皮中P53和C-erbB-2表达的临床意义. 世界华人消化杂志2006;14(3
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赵松, 刘连新, 哈尔滨医科大学第一临床医学院普外科 黑龙江省哈尔滨市 150001
付英梅, 哈尔滨医科大学微生物教研室 黑龙江省哈尔滨市 150086
赵柏, 哈尔滨医科大学第二临床医学院泌尿外科 黑龙江省哈尔滨市 150086
赵松, 2000年哈尔滨医科大学外科学硕士, 主治医师, 主要从事普通外科肿瘤和细胞移植研究.
通讯作者: 刘连新, 150001, 黑龙江省哈尔滨市南岗区邮政街23号, 哈尔滨医科大学第一临床医学院普通外科.
liulianxin@medmail.com.cn
电话: 0451-53643849-5885 传真：0451-53658828
收稿日期: 2006-08-29 接受日期: 2006-09-28
Expression of P53 and C-erbB-2 and their significances in chronic atrophic gastritis
Song Zhao, Ying-Mei Fu, Bai Zhao, Lian-Xin Liu
Song Zhao, Lian-Xin Liu, Department of General Surgery, the First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Ying-Mei Fu, Department of Medical Microbiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Bai Zhao, Department of Urinary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Correspondence to: Lian-Xin Liu, Department of General Surgery, the First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. liulianxin@medmail.com.cn
Received: 2006-08-29 Accepted: 2006-09-28
Abstract
AIM:To investigate the expression of P53 and C-erbB-2 proteins in chronic atrophic gastritis (CAG) and their correlation with clinicopathological parameters in CAG.
METHODS: SP immunohistochemistry was used to detect the expression of P53 and C-erbB-2 proteins in normal gastric mucosa (n = 56), chronic atrophic gastritis with cystic dysplasia (n = 61), intestinal metaplasia (n = 73), atypical hyperplasia (n = 295) and early gastric carcinoma (n = 57). The relationship between the expression of P53 and C-erbB-2 and the clinicopathological characteristics were analyzed.
RESULTS: The positive rates of P53 and C-erbB-2 protein expression were increased with the malignant degrees of gastric tissues ......
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