诺和锐30治疗2型糖尿病的疗效观察
胰岛素类似物；预混；血糖控制；,2型糖尿病,,胰岛素类似物；预混；血糖控制；,2型糖尿病,1资料与方法,2结果,3讨论,参考文献：
摘要：目的：观察比较诺和锐30和诺和灵30R治疗2型糖尿病的临床疗效。方法：将64例2型糖尿病患者随机分成诺和锐30组和诺和灵30R组，治疗12周后，观察两种不同治疗方案患者空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1c)、体质指数(BMI)、胰岛素剂量变化及低血糖发生的情况。结果：(1)两组治疗后FBG、2 hPBG、HbA1c均明显下降(P<0.01)，但诺和锐30组餐后血糖、糖化血红蛋白下降更明显(P<0.05)；(2)诺和锐30组低血糖发生率明显低于诺和灵30R组(P<0.05)；(3)诺和锐30组胰岛素剂量、体质指数增加幅度高于诺和灵30R组，但差异无统计学意义(P>0.05)。结论：诺和锐30能更好地降低2型糖尿病的血糖水平，尤其是餐后血糖，且不增加低血糖的风险。关键词： 胰岛素类似物；预混；血糖控制； 2型糖尿病
The effects of insulin aspart 30 injection in treatment of type 2 diabetes
ZHANG Lei, LI Xiaolan, WANG Minzhe
(Department of Endocrinology， Fifth Affiliated Hospital，Xinjiang Medical University,Urumqi 830011, China)
Abstract：Objective: To evaluate the effect of insulin aspart 30 injection and novolin 30R prnfill in treament of type 2 diabetes(T2DM). Method: Sixtyfour patients with T2DM were randomly divided into two groups: insulin aspart 30 injection group and novolin 30R prnfill group. After 12 weeks, the levels of fasting plasma glucose(FBG), 2 hours postprandial glucose(2 hPBG), glycosylated hemoglobin A1c(HbA1c), bodymass index (BMI), insulin dosages, frequency of hypoglycemia were compared before and after the treament. Results: (1) FBG, 2 hPBG, HbA1c were significantly decreased in two groups (P<0.01), but insulin aspart 30 injection group was associated with a significantly lower 2 hPBG, HbA1c than novolin 30R prnfill group (P<0.05). (2) The frequency of hypoglycemia of insulin aspart 30 injection group was significantly lower than that of novolin 30R prnfill group (P<0.05). (3) The level of insulin dosages and bodymass index of insulin aspart 30 injection groups was higher than that of novolin 30R prnfill groups (P>0.05). Conclusion: Insulin aspart 30 injection can effectively decrease 2 hour postprandial glucose and frequency of hypoglycemia in type 2 diabetic patients. ......
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