[摘要] 目的 检测肺腺癌组织中nm23表达和p53基因外显子突变情况，寻找有助于准确预测局部肿瘤进展、分型、预后情况的临床参照指标。方法 应用PCR技术检测31例肺腺癌术后存档蜡块组织中nm23表达及p53基因外显子突变情况，并与肺腺癌的病理及临床指标进行相关性研究。结果 nm23表达及p53基因突变率分别为38.7%及48.86%。nm23和(或)p53基因突变与临床分期呈正相关(P<0.01)。结论 nm23表达和(或)p53基因突变与肺癌临床分期和生存相关。nm23基因表达及p53基因突变在判断肺腺癌细胞增殖、分化程度、恶性进度及预后转归方面有一定价值，可作为判断腺癌预后的参考指标，指导高危患者的进一步治疗。

    [关键词] nm23;p53;肺癌

    Expression of mutation and significance of tumor metastasis suppressor gene nm23 and p53 in lung cancer

    MAO Wei-min，CHEN Xu-feng，SHU Yue，et al.Zhejiang Hospital，Hangzhou 310013，China

    [Abstract] Objective Our study was aimed to investigate whether nm23 expression and p53 gene mutation in the primary cardiocarcinoma correlated with tumor staging，recurrence，metastasis and patient survival time.Methods RT-PCR and PCR-SSCP were used to test the expression of nm23 ......