卵巢癌；Skp2；临床分期；病理分级；预后_

上皮性卵巢癌中Skp2蛋白的表达及临床意义

http://www.100md.com 《河北北方学院学报》 2006年第2期

卵巢癌；Skp2；临床分期；病理分级；预后,,卵巢癌；Skp2；临床分期；病理分级；预后,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的:探讨Skp2蛋白表达与上皮性卵巢癌发生、发展及预后评价的意义。方法：采用免疫组化法检测15例卵巢上皮性良性肿瘤、10例卵巢上皮性交界性肿瘤及58例上皮性卵巢癌中Skp2蛋白的表达情况。结果：Skp2在卵巢上皮性良性及交界性肿瘤中的表达均为阴性，而在上皮性卵巢癌中高表达，阳性率为4828%(28/58),Skp2在中低分化组、Ⅲ/Ⅳ期组及有淋巴结转移组分别高于高分化组(P<001)、Ⅰ/Ⅱ期组 (P<001)及无淋巴结转移组(P<001)。在不同年龄及组织类型的卵巢癌中表达无显著性差异。结论：Skp2在上皮性卵巢癌中表达，表达水平越高提示预后越差。

    【关键词】卵巢癌；Skp2；临床分期；病理分级；预后

    Clinical Significance and Expression of Skp2 Protein in Ovarian Epithelial Tumors

    LIU Yunchun, WEI Rongying, LI Jianping

    Department of Obstetrics and Gynecology,the First Affiliated Hospital，

    Hebei North University,Zhangjiakou,075000,Hebei CHina

    【ABSTRACT】 Objective：To investigate expression of Skp2 protein in ovarian epithelial tumors and its clinical significance. Methods:Test ovarian epithelian tumor tissues of 83 cases with monoclonal antibody Skp2 by immunohistochemistry.Results: The rate of positive expression of Skp2 was 4828% in ovarian epithelial cancers.No expression of gene protein appeared in borderline and benign ovarian tumor tissues.Conclusion: Skp2 gene participate in origination and development of ovarian epithelial cancers, and higher expression of Skp2 indicats worse prognosis. ......

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