喉癌；多药耐药；免疫组化；预后_

72例喉癌患者耐药基因与临床预后关系的初步探讨

http://www.100md.com 《河北北方学院学报》 2006年第2期

喉癌；多药耐药；免疫组化；预后,,喉癌；多药耐药；免疫组化；预后,1资料与方法,2试验结果,3讨论

     【摘要】目的:探讨喉癌患者中耐药基因P糖蛋白(Pgp)，谷胱苷肽S转移酶(GSTπ)，DNA拓扑异构酶Ⅱ(TopoⅡ)，胸苷酸合成酶(TS)表达的临床意义。方法：用免疫组化方法检测72例喉癌组织中的Pgp、GSTπ、TopoⅡ和TS，分析其与临床病理资料及预后的相关性。结果：72例喉癌患者中，Pgp阳性66例、GSTπ阳性50例、TopoⅡ阳性28例、TS阳性12例。Pgp的表达与病理分型、临床分期、淋巴转移及局部复发均相关，GSTπ、TopoⅡ的表达与淋巴结转移相关，TS的表达与各项指标均无明显相关性。患者的病理分级、临床分期、术后是否复发及GSTπ的表达均与术后生存时间明显相关。结论：喉癌患者Pgp、TopoⅡ、GSTπ、TS的联合检测十分必要，病理分级、临床分期、术后复发及GSTπ可以作为判断喉癌患者预后的指标。

    【关键词】喉癌；多药耐药；免疫组化；预后

    Primary Study and the Kelationship Between Drug Resistance Gene and

    Clinical Prognosis in 72 Pationts with Laryngeal Squamous Carcinoma

    ZHANG Qingjun， ZHANG Fan， XU Guogang， et al

    Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital,

    Hebei North University,Zhangjiakou,075000，Hebei China

    【ABSTRACT】 Objective：To study the relationship between the expression of pglycoprotein(pgp),glutathionestranferaseπ(GSTπ),topoisomerase Ⅱ(TopoⅡ) and themidylate synthase(TS)and the clinical pathological characteristics of the patients with laryngeal squamous cell carcinoma.Methods:The expressions of pgp、GSTπ、TopoⅡ、TS proteins were detected by immunohistochemistry method in 72 patiens with laryngeal squamous cell carcinoma who were followed up more than five years.Results:The expression of pgp was associated with histological grading、UICC staging、lymph node metastasis and recurrence; The expression of GSTπand TopoⅡwas associated with lymph node metastasis; survival rate was correlated with histological grading、UICC staging、recurrence and GSTπ.Conclusion: Histological grading、UICC staging、recurrence and the expression of GSTπcan be redarded as progonosis facters in laryngeal carcinoma. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/11/03/27/49/47.htm

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