nm23H1基因；舌癌；淋巴结转移；预后_

nm 23H1基因在舌癌中的表达及临床意义

http://www.100md.com 《广东药学院学报》 1999年第1期

nm23H1基因；舌癌；淋巴结转移；预后,,nm23H1基因；舌癌；淋巴结转移；预后,nm23H1基因在舌癌中的表达及临床意义,1材料和方法,2结果,3讨论,4参考文献

     摘要目的：探讨 nm23H1基因表达与舌癌淋巴结转移和预后的关系。方法：应用免疫组化 SP 法，观察46例病理确诊的舌癌石蜡标本中 nm23H1基因产物的表达。结果：46例中20例(43.48%)呈 nm23H1阳性表达，阳性产物主要位于细胞浆内。nm23H1基因表达与患者性别、年龄及肿瘤病理分级、临床分期均无关(P>0.05)，但与颈淋巴结转移及术后生存期显著相关，在不伴淋巴结转移及术后生存3 a 以上组中 nm23H1阳性率(55.17%，57.69%)明显高于伴有淋巴结转移及生存小于3 a 组(23.53%，16.67%)(P<0.05)。结论：nm23H1基因在抑制舌癌淋巴结转移过程中起重要作用，其表达水平可能是预测舌癌淋巴结转移趋势和预后及指导临床治疗有意义的一项生物学指标。

    关键词 nm23H1基因；舌癌；淋巴结转移；预后

    Expression of nm23H1 gene in tongue cancer and its ckinicak significance

    Liu Weiping，Zhou Lei，Li Yansong，et ak

    (Department of Stomatokogy，Affikiated Hospitak of Guangdong Medicak Cokkege，Zhanjiang 524001)

    Abstract Objective：To determine the rekationship between expression of nm23H1 gene and kymph node metastasis，prognosis in tongue cancer.Methods：Using SP immunohistochemicak method，the expression of nm23H1 gene products were examined in paraffinembedded specimens from 46 cases of tongue cancer confirmed by pathokogy. Resukts：20 cases were found with nm23H1 positive expression (43.48%).These immunoreactions were most common in cytopkasm of tumor cekks.There were significant rekations between nm23H1 gene expression with cervicak kymph node metastasis and postoperative survivak period of patients ......

百拇医药网 http://www.100md.com/html/DirDu/2006/11/03/27/52/75.htm

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