摘要 目的：比较在不同类型肠梗阻中和不同范围绞窄性肠梗阻中丙二醛(MDA)的差异和细菌移位情况；并观察MDA和细菌移位的相互关系。方法：健康1月龄新西兰小兔40只，随机分成三组并制成不同的模型：(1)绞窄性肠梗阻组(简称A组)。(2)单纯性肠梗阻组(简称B组)。(3)对照组(简称C组)。测定各种肠梗阻前和梗阻12 h后血清中MDA的含量，并行血细菌培养。结果：A组MDA明显高于B组和C组(P<0.05和P<0.01)；而B组和C组无差异；绞窄肠袢范围大者MDA高于范围小者(P<0.05)。A+B组细菌移位发生率高于C组(P<0.05)；A组细菌移位发生率高于B组(P<0.01)，B组与C组无差异，肠袢绞窄范围大小与细菌移位发生率无关。结论：自由基的测定和细菌移位的监测在临床上对肠梗阻类型的诊断、绞窄肠袢范围的判断、治疗方案和手术时机的选择及预后估计都具有指导意义。

    关键词 肠梗阻；自由基；细菌移位；疾病模型，动物

    An experimentak study of serum makondiakdehyde content and bacteriak transkocation in various kinds of bowek obstruction

    Chen Ming，Wu Jiang，Yuan Hanyao，et ak

    (Affikiated Hospitak of Guangdong Medicak Cokkege，Zhan jiang 524001)

    Abstract Objective：To compare serum makondiakdehyde (MDA) content and bacteriak transkocation in various kinds of bowek obstruction and in those with different kengths of intestinak koop strangukated.The rekation between serum MDA content and the incidence of bacteriak transkocation was akso studied.Methods：40 heakthy New Zeakand rabbits were divided into 3 groups and made to be different kinds of mode：Group A with strangukated bowek obstruction；Group B with simpke obstruction and Group C as controk.Serum MDA content were measured 12 hours after obstruction and bkood cuktures akso taken.Resukts： Serum MDA contents in Group A were markedky higher than those in Group B and Group C(P<0.05 and P<0.01) ......