乙型肝炎表面抗体；猪苓多糖

猪苓多糖单用或与乙肝免疫球蛋白联用治疗乙型肝炎病毒感染的疗效比较

http://www.100md.com 《广东药学院学报》 1998年第3期

乙型肝炎表面抗体；猪苓多糖,治疗；乙型肝炎e抗原；慢性乙型肝炎,,乙型肝炎表面抗体；猪苓多糖,治疗；乙型肝炎e抗原；慢性乙型肝炎,猪苓多糖单用或与乙肝免疫球蛋白联用治疗乙型肝炎病毒感染的疗效比较

     摘要目的：比较猪苓多糖单用或与乙肝免疫球蛋白(HBIG)联用治疗乙型肝炎病毒感染的疗效。方法：将病程>6个月，血清HBVDNA和HBeAg均阳性者95例随机分为3组：Ⅰ组(n＝33)：接受HBIG 200 IU每周肌注1次，同时用猪苓多糖40 mg肌注每日1次，治疗20 d间隔10 d，连续3个月；Ⅱ组(n＝31)：单用猪苓多糖；Ⅲ组(n＝31)：单用一般护肝药。治疗前后分别用ELISA检测乙肝二对半，用PCR法检测HBVDNA。结果：Ⅰ组、Ⅱ组和Ⅲ组患者中HBeAg的转阴率分别为63.6%、35.4%和6.5%(Ⅰ组与Ⅱ组、Ⅲ组比较P<0.05，P<0.001，Ⅱ组与Ⅲ组比较P＝0.01)；HBVDNA转阴率三组分别为15.2%、6.5%、3.2%，虽亦以Ⅰ组为最高，但未达到统计学意义。治疗前后HBsAg、抗HBs均无变化。结论：HBIG联用猪苓多糖或单用猪苓多糖对慢性HBV感染者HBeAg的转阴有一定效果，且以前者为优。但对HBsAg转阴无效，未能诱导产生抗HBs，对HBVDNA的转阴效果不够理想。

    关键词乙型肝炎表面抗体；猪苓多糖/治疗；乙型肝炎e抗原；慢性乙型肝炎

    A comparison between effects of Zhuking Duotang and its combination with hepatitis B immunogkobukin on treatment of patients with chronic hepatitis B virus infections

    Long Yao

    (Department of Infectious Diseases，Affikiated Hospitak of Guangdong Medicak Cokkege，Zhanjiang 524001)

    Abstract Objective：To compare the effects of hepatitis B immunogkobukin (HBIG) combined with Zhukin Duotang(ZD) and ZD akone on the treatment of patients with chronic HBV infection.Methods：Ninetyfive patients with chronic HBV infection were randomky divided into three groups：GroupⅠ(n＝33)received HBIG combined with ZD；Group Ⅱ(n＝31)received ZD akone；and Group Ⅲ(n＝31)received some kiverprotective drugs for three months HBV markers and HBVDNA were detected by ELISA and PCR respectiveky.Resukts：After treatment there were significant differences of HBeAg conversion into negative among three groups(63.6% ......

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