不同类型大鼠；左心室流出道；电活动；Na+K+ATPas

左心室流出道电活动改变中的作用

http://www.100md.com 《河北北方学院学报》 2006年第2期

不同类型大鼠；左心室流出道；电活动；Na+K+ATPase,,不同类型大鼠；左心室流出道；电活动；Na+K+ATPase,1材料与方法,2结果,3讨论,参

     【摘要】目的：探讨不同类型大鼠左心室流出道电活动改变与Na+K+ATPase活动之间的关系。方法：采用Wistar鼠、SpragueDawley大鼠(SD)、自发性高血压大鼠(SHR)及盐性高血压大鼠(SDSa)，酶学方法测定其左心室流出道区域Na+K+ATPase活性。用细胞内记录方法引导该区的静息电位(RP)、动作电位幅度(APA)、0相最大除极速度(Vmax)及动作电位时程(APD)。结果:SHR的RP、APA及Vmax与Wistar鼠该三项指标相比无显著差异，但APD明显较Wistar鼠延长，Na+K+ATPase活性明显低于Wistar鼠；SD鼠各项指标与Wistar鼠无显著差异；SDSa鼠的RP、APA与SD鼠相比无显著差异，但Vmax明显低于SD鼠，APD明显缩短，Na+K+ATPase活性明显低于SD鼠，但与SHR无显著差异。结论：左心室流出道电活动改变与其Na+K+ATPase活性关系不大，可能与膜离子通透性有关。

    【关键词】不同类型大鼠；左心室流出道；电活动；Na+K+ATPase

    Function of Na+K+ATPase Activity Change in

    Left Ventricular Outflow Tract of Different Rats

    JIAO Hong, MA Jianwei, QIU Liying

    Department of physiology, Hebei North University, Zhangjiakou,075000，Hebei China

    【ABSTRACT】 Objective:To study the relationship between the electric potential of left ventricular outflow tract (LVOT) and the activity of Na+K+ATPase of LVOT from different kinds of rats.Methods:The activity of Na+K+ATPase of LVOT was measured by the enzymologic method in Wastar rats, SpragueDawley rats, spontaneously hypertensive rats and saline hypertensive rats. The electrophysiological parameters, resting potential (RP), amplitude of action potential (APA), maximal rate of depolarization of phase 0 (Vmax) and duration of action potential (APD) were intracellularlly recorded.Results:There was no significantdifference between spontaneously hypertensive rats (SHR) and Wistar rats in the RP,APA, and Vmax. But in SHR, ......

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