发作性睡病与HLA-DQB1*0602基因的相关性研究
发作性睡病;HLA基因;易感性,,],发作性睡病;HLA基因;易感性,材料与方法,2结果,3讨论,[参考文献]
[摘要] 目的 探讨发作性睡病与HLA-DQB1基因的相关性。方法 对30例发作性睡病患者的临床资料进行分析。用序列特异性引物-聚合酶链反应(PCR-SSP)分型技术测定HLA-DQB1等位基因,并与44例健康人检测的数据进行比较。结果 发作性睡病患者组DQB1*0602基因频率为40%，与正常对照组9.09%相比较明显增高；未检出DQB1*0401-0402基因，与正常对照组9.09%相比较，经统计学分析，差异有显著性(P<0.05)。 结论 HLA-DQB1*0602基因为中国发作性睡病人群的易感基因；HLA-DQB1*0401-0402基因为中国发作性睡病人群的保护基因。[关键词] 发作性睡病;HLA基因;易感性
Study on the association between HLA-DQB1*0602 genes and narcolepsy
JIANG Tianshu ,ZHOU Ye, CHEN Yan,et al. Labortary Diagnostics, Changzheng Hospital,Second Military Medical University,and Clinical Immunology Center of PLA, Shanghai 200003, China
[Abstract] Objective To investigate the association between HLA-DQB1 genes and narcolepsy.
Methods HLA typing were performed in 30 patients with narcolepsy by HLA-DQB1 resolution PCR-SSP(sequence specific primers),then the frequencies of alleles were analyzed compared with normal controls. ......
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