感染后与非感染后IBS患者结肠黏膜SP与IL-2、IFN-γ表达的相关性
http://www.100md.com
鞠 辉, 张小芳, 刘希双, 魏良洲
肠易激综合征;P物质;白细胞介素-2;干扰素-g;免疫组化鞠辉,张小芳,刘希双,魏良洲.感染后与非感染后IBS患者结肠黏膜SP与IL-2、IFN-g表达的相关性. 世界华人消化杂志2006
 |
| 第1页 |
参见附件(1593KB，5页)。
鞠辉, 刘希双, 青岛大学医学院附属医院内镜中心 山东省青岛市 266003
张小芳, 烟台市牟平人民医院消化内科 山东省烟台市 264100
鞠辉, 2006年毕业于青岛大学医学院消化内科专业, 硕士, 现在青岛大学医学院附属医院内镜中心工作, 主要从事消化内窥镜诊治工作.
通讯作者: 魏良洲, 266003, 山东省青岛市, 青岛大学医学院附属医院消化内科. weiliangzhou62@126.com
电话: 0532-82911303, 82911525
收稿日期: 2006-08-10 接受日期: 2006-09-01
Correlations of substance P with interleukin-2 and interferon-γ expression in colonic mucosa of patients with post- and non-post-infectious irritable bowel syndrome
Hui Ju, Xiao-Fang Zhang, Xi-Shuang Liu, Liang-Zhou Wei
Hui Ju, Xi-Shuang Liu, Center of Endoscopy, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Xiao-Fang Zhang, Department of Gastroenterology, Muping People’s Hospital, Yantai 264100, Shandong Province, China
Correspondence to: Liang-Zhou Wei, Department of Gastroenterology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China. weiliangzhou62@126.com
Received: 2006-08-10 Accepted: 2006-09-01
Abstract
AIM: To investigate relationship between substance P (SP) activity and expression of interleukin-2 (IL-2) and interferon-g (IFN-g) in colonic mucosa from patients with post-infectious irritable bowel syndrome (PI-IBS).
METHODS:Mucosal biopsy samples were obtained by colonoscopy from the descending colon and rectum of 77 patients (n = 21 and 52, for PI-IBS and non- PI-IBS, respectively) and 30 controls. The expression of SP, IL-2, and IFN-g were determined by immunohistochemistry.
RESULTS:The expressions of SP was significantly higher in the descending colon and rectum mucosa from PI-IBS patients than that from non-PI-IBS patients (t = 2.321, 2.452, 2.414, 2.520, P < 0.05) and controls (t = 3.623, 3.722, 3.454, 3.561, P < 0.01). The positive rates of IL-2 and IFN-g were also markedly higher in PI-IBS patients than those in the controls (c2 = 13 ......
您现在查看是摘要介绍页，详见PDF附件(1593KB，5页)。