原发性肝癌患者血清leptin, VEGF和AFP表达的意义
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侯振江, 王秀文, 张丽华, 周秀艳, 戴殿禄,
肝细胞癌;瘦素;血管内皮生长因子;甲胎蛋白;体重指数,原发性肝癌患者血清leptin,VEGF和AFP表达的意义,侯振江,张丽华,闫金辉,王秀文,戴殿禄,周秀艳,侯振江,通讯作者:,C
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侯振江, 张丽华, 闫金辉, 沧州医学高等专科学校 河北省沧州市 061001
王秀文, 戴殿禄, 沧州市中心医院 河北省沧州市 061001
周秀艳, 唐山市人民医院 河北省唐山市 063001
侯振江, 副教授, 从事实验诊断和医学检验教学、临床和科研25年, 发表论文、译文、综述286篇, 参编和主编教材、专著14部.
河北省科学技术发展和规划项目, No. 052761288
通讯作者: 侯振江, 061001, 河北省沧州市迎宾大道高教区, 沧州医学高等专科学校. houzhenjiang@sina.com
电话: 0317-5507805
收稿日期: 2006-06-13 接受日期: 2006-08-22
Clinical significance of serum leptin, vascular endothelial growth factor and alpha-fetoprotein expression in hepatocelluar carcinoma
Zhen-Jiang Hou, Xiu-Wen Wang, Li-Hua Zhang, Xiu-Yan Zhou, Dian-Lu Dai, Jin-Hui Yan
Zhen-Jiang Hou, Li-Hua Zhang, Jin-Hui Yan,Cangzhou Medical College, Cangzhou 061001, Hebei Province, China
Xiu-Wen Wang, Dian-Lu Dai, Cangzhou Central Hospistal, Cangzhou 061001, Hebei Province, China
Xiu-Yan Zhou,Tangshan Municipal People’s Hospital, Tangshan 063001, Hebei Province, China
Supported byDevelopment and Programming Foundation of Science and Technology of Hebei Province, No. 052761288
Correspondence to:Zhen-Jiang Hou, Cangzhou Medical College, Yingbin Road, Cangzhou 061001, Hebei Province, China. houzhenjiang@sina.com
Received:2006-06-13 Accepted:2006-08-22
Abstract
AIM: To explore the expression of serum leptin (Lep), vascular endothelial growth factor (VEGF) and alpha-fetoprotein (AFP) and their clinical significances in hepatocelluar carcinoma (HCC).
METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum Lep, VEGF and AFP levels in 146 patients with HCC, 31 patients with liver cirrhosis and 30 healthy controls. The correlations Lep, VEGF, and AFP expression with clinical indexes were analyzed.
RESULTS: The serum Lep level was correlated with body mass index (BMI) in HCC patients (r = 0.64, P < 0.01), and significantly lower than that in cirrhotic patients and healthy controls (19 μg/L vs 35, 27 μg/L, P < 0 ......
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