癌基因C-erbB-2在结直肠癌中的表达及其与浸润转移的相关性
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李 巍, 田素礼, 李 季
C-erbB-2;结直肠肿瘤;免疫组织化学;浸润;转移,李巍,田素礼,李季,李巍,通讯作者:,Expressionofontog
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李巍, 田素礼, 李季, 哈尔滨医科大学附属第二医院普外科 黑龙江省哈尔滨市 150086
李巍, 2004年哈尔滨医科大学硕士生, 主要从事结直肠肿瘤的基因诊断和治疗的研究.
通讯作者: 田素礼, 150086, 黑龙江省哈尔滨市学府路246号, 哈尔滨医科大学附属第二医院普外科. stanley81@163.com
电话: 0451-86605044
收稿日期: 2006-07-25 接受日期: 2006-08-22
Expression of ontogene C-erbB-2 and its correlations with invasion and metastasis in colorectal carcinoma
Wei Li, Su-Li Tian, Ji Li
Wei Li, Su-Li Tian, Ji Li,Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Correspondence to:Su-Li Tian, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. stanley81@163.com
Received:2006-07-25 Accepted:2006-08-22
Abstract
AIM: To investigate the expression of oncogene C-erbB-2 and its significance in colorectal carcinoma.
METHODS: Immunohistochemical technique (SP) was performed to detect the expression of oncogene C-erbB-2 in 69 cases of colorectal carcinoma and its corresponding tissues from patients received curative resection.
RESULTS: The expression of C-erbB-2 was mainly found in cell membrane and cytoplasm of colorectal carcinoma tissues with a positive rate of 65.2% (45/69), which was significantly higher than that in the tissues of benign tumor (2/20, P < 0.05). The positive rate of C-erbB-2 expression had significant difference between colorectal cancer (65.2%) and its surrounding tissues (mesenteric: 47.8%, normal cancer-adjacent: 30.4%, distant resection margin: 13.0%; all P < 0.05). The expression of C-erbB-2 was significantly correlated with the gross morphology, differentiation of the tumor cells, clinical staging (Dukes staging) and lymph node metastasis (P < 0.05), but not with the age, sex of patients, tumor location and size, as well as distant metastasis (P > 0.05). The expression of oncogene C-erbB-2 in the mesenteric margin and cancer-adjacent tissues was markedly different between routine histology and immunohistochemistry (P < 0 ......
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