乳腺癌;_CerbB2;_ER;_PR

乳腺癌组织中CerbB2基因蛋白的表达及其意义

http://www.100md.com 《新疆医科大学学报》(新) 2006年第10期

乳腺癌;,CerbB2;,ER;,PR,;淋巴结转移,,乳腺癌;,CerbB2;,ER;,PR,;淋巴结转移,1材料与方法,2结果,3

     摘要: 目的：探讨癌基因蛋白CerbB2与乳腺癌组织学分型、淋巴结转移、雌激素受体(ER)和孕激素受体(PR)的关系。方法：对179例乳腺癌患者采用免疫组化法检测CerbB2蛋白在乳腺癌组织中的表达。结果：179例乳腺癌组织中CerbB2表达的阳性率为29.6%, 在导管原位癌中CerbB2表达率为52.9%,其它病理类型中CerbB2表达均较低(<45%),导管原位癌CerbB2蛋白表达率与浸润性导管癌、浸润性小叶癌比较差异有统计学意义，CerbB2蛋白阳性表达组患者的淋巴结转移率明显高于阴性组(P<0.05), 并与雌、孕激素受体呈负相关关系。结论： CerbB2表达与乳腺癌组织学分型、淋巴结转移有关，可作为乳腺癌预后判断的指标之一。

    关键词乳腺癌; CerbB2; ER; PR ;淋巴结转移

    Study of CerbB2 gene expression in breast cancer tissue

    FENG Min, HUANG Yanchun, ZHAO Feng

    (Department of Clinical Laboratory, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China)

    Abstract: Objective: To investigate the expression and the signification of CerbB2 gene in breast cancer and its relationship with histological type, lymph node metastasis, ER and PR. Methods: The expression of CerbB2 in 179 breast cancer was studied with immunohistochemical method. Results: The positive rate of CerbB2 was 29.6% in 179 breast cancer, the positive rates of CerbB2 in ductal carcinoma in situ were 52.9%, it was low in others histological type (<45%). There was significant difference between them. Significant relationship was also found between positive expression of CerbB2gene and lymph node metastasis (P<0.05), and it was in negative correlation with ER and PR. Conclusion: CerbB2 maybe an important role in the process of carcinogenesis in the breast, and be used as a useful marker for the early diagnosis and distant metastasis in breast cancer. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/11/29/30/33/80.htm

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