摘要：目的：观察异常黑胆质载体动物模型实验动物的支配器官形态学改变，探讨异常黑胆质证的病理解剖学基础。方法：选择健康ICR雄性小鼠30只，分为模型组和正常对照组，每组15只。各组造模后眼球放血处死实验动物，并迅速取出支配器官脑(下丘脑)、心脏、肝脏，采用HE染色，光学显微镜下进行组织学观察，观察和比较2组实验动物支配器官形态学改变。结果：与正常对照组相比,模型组小鼠支配器官组织有明显的形态学改变。模型组下丘脑星形胶质细胞肿胀，间质血管中、重度扩张。心肌脂肪浸润，间质血管扩张。肝脏肝细胞再生程度明显，存在点状坏死、间质炎性细胞浸润。结论：机体支配器官的形态学改变可能是异常黑胆质产生的部分病理学基础。

    关键词： 异常黑胆质载体动物模型； 支配器官； 形态学改变

    Morphological changes of dominating organs of abnormal savda syndrome animal model

    Nijat·Rahman， Aynur·Matsidik， Halmurat·Upur, et al

    (Department of Pathology, Department of Uighur Medicine, Xinjiang Medical University,Urumqi 830054, China)

    Abstract: Objective: Observe Morphological changes of Dominating Organs of Abnormalsavda syndrome animal model and investigate the pathological basis of abnormal savda. Methods: Abnormal savda syndrome animal model was made, then take its brain, cardiac muscle, liver and observe histological changes of these organs by optic microscope. Furthermore to observe and compare dominating organs′ histological changes in abnormal savda syndrome by using comparing study. Results: Microscopic examination showed swelling of hypothalamic cells, interstitial angiectasis in the hypothalamus. And there was adipose cells infiltration and interstitial angiectasiss on cardiac muscles. Liver cells was regeneration, point necrosis and liver tissue inflammatory infiltration. Conclusion: Comparing to control group, model group has obvious morphological changes in dominating organs. The morphological changes of dominating organs might be partly pathology basis of abnormal savda. ......