[摘要] 目的 探讨颅脑创伤患者脑脊液β2-微球蛋白的变化及其临床意义。方法 在患者入院后第1、4、10天分别测定脑脊液β2-微球蛋白水平，并观察其与急性生理和慢性健康评分Ⅱ(APACHE Ⅱ)、患者的预后及死亡率的关系。 结果 脑脊液β2-微球蛋白的水平呈先升高后降低变化，与脑水肿的演变相关。脑脊液β2-微球蛋白的高低与患者的预后呈负相关。APACHE Ⅱ积分越高，脑脊液β2-微球蛋白的水平也越高(P<0.05)，且APACHE Ⅱ30分以上，死亡率明显增加(35.1%)。结论 颅脑创伤患者脑脊液β2-微球蛋白测定对判断患者病情严重程度、观察治疗效果及判定预后有一定意义。

    [关键词] β2-微球蛋白；脑脊液；颅脑损伤

    Clinical value of beta-2-microglobulin in cerebrospinal fluid in patients with craniocerebral injury

    XIE Xiao-hong,CAI Jin-fang,WANG Zhi-hua,et al.

    ICU,Central Hospital,Nanhui District,Shanghai 201300,China

    [Abstract] Objective To study the change and the clinical significance of beta-2-microglobulin(β2-MG)in cerebrospinal fluid in craniocerebral injury patients.

    Methods In the 1,4,10 d,the levels of β2-MG in cerebrospinal fluid were determined,and then compared with its APACHE Ⅱ,progrosis and mortality.

    Results The levels of β2-MG in cerebrospinal fluid increased on the first day and the forth day,then decreased,related with the changes of cerebral edema.Levels of β2-MG were negatively correlated with the progrosis of patients.The higher its APACHE Ⅱ was,the higher that the levels of β2-MG would be.The APACHE Ⅱ which was above 30,the morbility were significantly higher (35.1%). ......