PEI Zhaoª²Hui1, MA Hong1, HU Deª²Hua2, ZHU Miaoª²Zhang3, HE Jianª²Gui1, PENG Longª²Yun1, WANG Liª²Jun1

    1Department of Cardiology, First Hospital, Sun Yatª²sen University, Guangzhou 510080, China, 2Infirmary of PLA 264 Hospital, Taiyuan 030001, China, 3Department of Physiology, School of Basic Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To observe the effect of angiotensinª²(1ª²7) [Angª²(1ª²7)] on the expressions of metalloproteinasesª²1 (MMPª²1) protein and tissue inhibitor of matrix metalloproteinases (TIMPª²1) mRNA and study the mechanism by which Angª²(1ª²7) inhibits the myocardial hypertrophy. METHODS: Rats were randomized into 3 groups: control group, norepinephrine(NE) group and NE+Angª²(1ª²7)group (n=10 per group). The expression of MMPª²1 protein was determined by Western blot and the expression of TIMPª² 1 mRNA by RTª²PCR in rat hearts. RESULTS: Compared with the control group, the expression of MMPª²1 protein decreased significantly in NE group (P<0.01), and increased in NE+Angª²(1ª²7) group (P<0.01). Compared with the control group, the expression of TIMPª²1 mRNA decreased significantly in NE+Angª²(1ª²7)group (P<0.01), and increased in NE group (P<0.01). CONCLUSION: The Angª²(1ª²7) can inhibit myocardial hypertrophy. ......