[摘要] [目的] 探讨C反应蛋白(CRP)与慢性环孢素A(CsA)肾毒性肾小管间质纤维化的关系. [方法] 给雄性Sprague-Dawley大鼠皮下注射CsA4周，建立慢性CsA肾毒性动物模型.采用胶乳增强免疫比浊法、免疫比浊法以及免疫组织化学染色方法检测对照组及慢性CsA肾毒性组大鼠血清高敏CRP(hs-CRP)、CRP及肾内CRP的水平;采用三色染色方法观察肾小管间质纤维化程度;以直线相关分析法对CRP与肾小管间质纤维化程度间的关系进行分析. [结果] 慢性CsA肾毒性组与对照组血清CRP和hs-CRP的含量水平间无显著性差异，与肾小管间质纤维化程度无相关关系;慢性CsA毒性组大鼠肾内CRP的表达显著高于对照组，与肾小管间质纤维化程度呈正相关(r=0.862). [结论] 慢性CsA肾毒性肾小管间质纤维化与肾内CRP的表达水平密切相关，与血清CRP的含量无关.

    [关键词] 肾小管间质纤维化;C反应蛋白;大鼠

    Relationship between C-reactive protein and tubulointerstitial fibrosis

    LI Can 1 ，JIN Ying-shun 1 ，CHEN Ying 1 ，YANG Chul-woo 2

    (1.Department of Interrenal Medicine，Affiliated Hospital of Yanbian University，Yanji133000，Jilin，China;2.Department of Interrenal Medicine，KangNam St.，Mary's Hospital，The Catholic University of Korea，Korea)

    ABSTRACT:OBJECTIVE To study the relationship between C-reactive protein(CRP)and tubulointerstitial fibrosis(TIF)in a model of chronic cyclosporine(CsA)nephrotoxicity.METHODS Chronic CsA nephrotoxicity was induced in Sprague-Dawley rats by administering CsA for4weeks.Serum CRP ......