[摘要] [目的] 研究廿烷碳五烯酸(EPA)对肺腺癌细胞的抑制增殖作用. [方法] 在细胞培养、动物实验及临床应用实验基础上，进行细胞凋亡、肿瘤细胞活力及急性毒性实验. [结果] EPA对肺腺癌细胞具有明显地抑制增殖作用，EPA作用后肺腺癌细胞周期的G 1 ，S期细胞百分率明显降低，随时间的延长及剂量增大而效能增强;EPA可引起细胞凋亡;EPA作用后血清TNF-α，IL-6，IL-1水平显著降低. [结论] 长期接受EPA治疗可调节机体炎症反应，提高机体免疫力，而且单剂量应用即具有抑制肿瘤细胞生长的作用，呈时间-剂量依赖性.

    [关键词] 廿烷五稀酸;细胞凋亡;细胞因子;肺腺癌

    YIN Zeng，YAO Xia，SHI Jun * ，HAN Guang-hai，LI Ming-zhe

    (Department of ICU，Affiliated Hospital of Yanbian University，Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To study of inhibitory effects of of EPA to the adenocarcinoma of lung cell.METHODS Based on cell developing，animal test and clinic test，the cell apoptosis and cancer cell vitality and acute poison tests were used.RESULTS EPA obviously depress and kill adenocarcinoma of lung cell EPA working on adenocarcinoma of lung cell life circle，and EPA works on adenocarcinoma and the more dose EPA works on ......