MA Sai1, JIA Jun2, DUAN Yuanª²Yuan2, ZHANG Shaoª²Feng2, WANG Zhongª²Yi2

    1Team 16, Department of Stomatology, 2Department of Prosthodontics, College of Stomatology, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To evaluate the biological safety of polypyrrole film electropolymerized on Tiª²substrates for possible use as dental implant. METHODS: The biological safety was evaluated through the experiments including hemolysis test, shortª²term systemic toxicity test, oral mucous membrane irritation test and cytotoxicity test (MTT test). RESULTS: The material had no hemolytic activities. The shortª²term systemic toxicity test results showed that no histopathological changes were found in the vital organs such as heart, kidney and liver of tested animals. No local response was observed in the oral mucosa membrane irritation test. MTT revealed that L929 cells grew well in the extract and the grade of cytotoxicity was zero. CONCLUSION: The Tiª²substrates coated with polypyrrole film have good biological safety.

    ¡¾Keywords¡¿ dental implants; polypyrrole; biological safety; biocompatible materials ......