[摘要] [目的] 优化化合物MCC的合成工艺. [方法] 以6-羟基-2-萘甲醛为原料，经Knoevenagel缩合反应、Williamson成醚反应及催化氢化反应合成得到目标化合物. [结果] 中间体及产物的结构经IR， 1 HNMR和MS确证，总产率为66.5%. [结论] 合成工艺反应条件温和，操作简便，反应可控性好，适合于工业生产.

    [关键词] 化学，药物;糖尿病;合成

    Improvement of synthesis of novel antidiabetic agent MCC-555

    SUN Liang-peng，WU Yan-ling，ZHENG Guang-hao，PIAO Hu-ri * (Yanbian University College of Pharmacy，Yanji133000，Jilin，China)

    ABSTRACT:OBJECTIVE To synthesize the compound MCC-555that possessing antidiabetic activity.METHODS MCC-555was synthesized using6-Hydroxy-napthalene-2-carbaldehyd through Knoevenagel condensation reaction ......