阿立哌唑_氯米帕明_强迫症_____阿立哌唑

阿立哌唑与氯米帕明治疗强迫症的疗效对照分析

http://www.100md.com 《四川精神卫生》 1999年第3期

阿立哌唑,氯米帕明,强迫症,,阿立哌唑,氯米帕明,强迫症,1对象和方法,2结果,3讨论,参考文献

     【摘要】目的比较阿立哌唑与氯米帕明治疗强迫症的疗效及不良反应。方法将符合CCMD-3诊断标准的强迫症患者62例，随机分成研究组(阿立哌唑组)29例，对照组(氯米帕明组)33例。分别应用临床疗效评定标准、YaleBrown强迫症量表(YBOCS)和Hamilton抑郁量表(HAMD)、自编不良反应出现频率表，分别评定疗效及不良反应。结果研究结束时，两组自身在治疗前后的临床疗效、YBOCS量表及Hamilton量表的减分率均显示有显著性差异(P<001)。阿立哌唑组和氯米帕明组的有效率分别为53%和56%，但是两组之间的疗效则无显著性差异(P>005)。两组不良反应格局略有不同。结论结果显示阿立哌唑在治疗强迫症时，其临床疗效与氯米帕明相当，而不良反应虽有所差异，但不影响治疗。

    【关键词】阿立哌唑氯米帕明强迫症

    A comparative efficacy of aripiprazole and chlorimipramine in the treatment of obsessivecompulsive disorder.ZHOU Xiaodong,DING Yongtao,LI Xiuzhen,et al.The General Department of Psychiatry,The 256th Hospital of PLA,Zhengding,Hebei 050800,China

    【Abstract】Objective To compare curative effect and adverse reaction of aripiprazole versus chlorimipramine in the treatment of obsessivecompulsive disorder.Methods A total of 62 patients who met the CCMD-3 criteria for obsessivecompulsive disorder were randomsed into two groups:One group was treated with aripiprazole(n=29) and other group with chlorimipramine(n=33) for 16 weeks.The efficacy was measured with the criteria of clinical effect,the YaleBrown ObsessiveCompulsive Scale(YBOCS) and Hamilton Depression Scale(HAMD).The adverse reaction was assessed by Homemade Treatment Emergent Symptoms Scale.Results The significamt improvement rate of aripiprazole was 53% and other was 56%(P<001),but there no significant differences between the two groups(P>005) .The adverse reaction of two groups were different in some sort.Conclusions The curative effect of aripiprazole versus chlorimipramine in the treatment of obsessivecompulsive disorder were similar and the adverse reaction of aripiprazole was different from chlorimipramine but no inpact in clinical use. ......

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