[摘 要] 目的: 研究白细胞介素-1(IL-1)B和IL-1受体拮抗剂(IL-1ra)基因多态性与胃癌易患性的关系。 方法: 应用基因芯片、聚合酶链式反应(PCR)和PCR-限制性片段长度多态性(PCR-RFLP)技术对65例胃癌患者和71例健 康对照IL-1B-31和-511及IL-1ra基因多态性进行了分析。结果: 与对照组相比，胃癌患者IL-1B-31T/T携带者、IL- 1B-511C/C携带者显著增加(χ2=6.014，P<0.01; χ2 =9.533 P <0.001)。其他等位基因或基因型未见差异。结论: 胃癌的易患性与IL-1B-31TT和IL-1B-511CC基因型可能有关。

    [关键词] 白细胞介素-1B; IL-1受体拮抗剂; 基因多态性; 基因芯片; 胃癌

    Relationship between Interleukin-1B and Interleukin-1 receptor antagonist gene polymorphisms and susceptibility to gastric cancer

    GAO Wei， CHUI Xia， HU An-la， XING Pei-xiang， SUN Yu-ping ， WANG Yun-shan

    (Jinan Central Hospital，Clinical Medical College of Shandong University， Jinan Shandong 250013，China)

    [Abstract] Objective: To study relationship between interleukin-1B gene and interleukin-1 receptor an- tagonist gene polymorphisms and susceptibility to gastric cancer. Methods: A total of 71healthy controls and 65 patients with gastric cancer were genotyped by gene chip，polymerase chain reaction (PCR) and PCR- restriction fragment length polymorphism (PCR-RFLP) for IL-1B-31 and -511 single nucleotide poly-morphism (SNP) of IL-1B promoter ......