胆囊切除术_腹腔镜；细胞因子；内皮素；C反应蛋白_

腹腔镜胆囊切除术对细胞因子、内皮素和C反应蛋白水平的影响

http://www.100md.com 《腹腔镜外科杂志》 2006年第5期

胆囊切除术,腹腔镜；细胞因子；内皮素；C反应蛋白,,胆囊切除术,腹腔镜；细胞因子；内皮素；C反应蛋白,1资料与方法,2结果,3讨论,参考

     【摘要】目的：探讨开腹与腹腔镜胆囊切除术(LC)2种方法对胆囊疾病患者血中细胞因子、内皮素和C反应蛋白的影响，比较两种方法对机体损伤的程度及安全性。方法：选择行剖腹胆囊切除术(OC)患者50例，LC患者50例，分别于术前和术后抽取静脉血检测IL2、IL6、NK细胞活性、CD4/CD8、内皮素、C反应蛋白含量并进行比较。结果：OC组IL2和NK细胞活性术后较术前下降(P<0.05)，IL6术后较术前明显上升(P<0.01)。IL6术后OC组较LC组上升(P<0.05)。OC组IL2术后较LC组降低(P<0.05)。CD4/CD8未发现明显变化。OC组血中内皮素术后含量明显高于LC组患者(P<0.01)，C反应蛋白于术后亦高于LC组。结论：研究表明LC损伤小，是一种安全可靠的手术方式。

    【关键词】胆囊切除术,腹腔镜；细胞因子；内皮素；C反应蛋白

    The influence of laparoscopic cholecystectomy and open cholecystectomy on the level of Cytokines,Endothelin and Creactive protein

    WANG Chen,LI Xusheng.

    Centre of Laparoscopic Surgery,the Second Hospital of Lanzhou University,Lanzhou 730030,China

    【Abstract】 Objective:To research the effect of laparoscopy cholecystectomy (LC) and open cholecystectomy (OC) on the plasma concentration of Cytokines,Endothelin (ET) and Creactive protein (CRP).Methods:The concentration of IL2,IL6,NK cell cytoactive,CD4/CD8,ET and CRP in the blood samples were assessed preand postoperation both laparoscopic (n=50) and open (n=50) cholecystectomy.Results:There was no significant difference in concentration of Cytokines after laparoscopic cholecystectomy. The level of IL6 was strongly increased after open cholecystectomy.But the level of IL2 and NK cell were decreased.IL6's level was increased and IL2's level was decreased in open procedure patients.There was no significant difference in CD4/CD8.Compared with post laparoscopic procedure patients.The level of ET and CRP of group OC were significantly higher than group LC.Conclusions:Laparoscopic cholecystectomy is a safe operation to the patients. ......

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