肝硬化与睾酮、雌二醇相互作用关系研究现状
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洪美珠, 陈国良
肝硬化;睾酮;雌二醇;相互作用,洪美珠,陈国良,通讯作者:,Currentstatusontheinteractionoftestosteronean
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洪美珠, 福建中医学院中西医结合专业2004级硕士研究生 厦门中医院肝病中心 福建省厦门市 361000
陈国良, 厦门中医院肝病中心 福建省厦门市 361000
通讯作者: 陈国良, 361000, 福建省厦门市仙岳路, 厦门中医院肝病中心. hongyys@sina.com
电话: 0592-5579536
收稿日期: 2006-09-03 接受日期: 2006-10-11
Current status on the interaction of testosterone and estradiol with liver cirrhosis
Mei-Zhu Hong, Guo-Liang Chen
Mei-Zhu Hong,Postgraduate from Fujian College of Traditional Chinese Medicine; Center of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, Fujian Province, China
Guo-Liang Chen,Center of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, Fujian Province, China
Correspondence to:Guo-Liang Chen, Center of Liver Diseases, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, Fujian Province, China. hongyys@sina.com
Received:2006-09-03 Accepted:2006-10-11
Abstract
Liver acts as one of the pivotal organs that are involved in the transformation and degradation in vivo of the sex hormones, such as testosterone and estradiol. However, the sex hormones are not degraded in the liver simply and passively. They themselves and their metabolites play key roles in the occurence and development of liver diseases. There are metabolic disorders of testosterone and estradiol in the cirrhotic patients; On the contrary, sex hormones have certain influences on the occurrence of liver cirrhosis, even hepatocellular carcinoma. Comprehensive understanding of this interaction relationship is significant for liver cirrhosis both in prevention and novel treatments. In this article, we probed into the expression of both testosterone and estradiol under the physiological and pathological state, respectively, as well as the influences of testosterone and estradiol on the pathogenesis and prognosis of cirrhosis.
Key Words: Liver cirrhosis; Testosterone; Estradiol; Interaction
Hong MZ, Chen GL ......
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