艾灸足三里和梁门穴诱导热休克蛋白70抗大鼠胃黏膜氧化损伤作用
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常小荣, 彭 娜, 易受乡, 彭 艳, 严 洁
艾灸;足三里;梁门;热休克蛋白70;丙二醛,常小荣,彭娜,易受乡,彭艳,严洁,通讯作者:,MoxibustionatZusanlian
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常小荣, 彭娜, 易受乡, 彭艳, 严洁, 湖南省中医学院针灸推拿学院 湖南省长沙市 410007
国家自然科学基金资助项目, No. 30572310
湖南省自然科学基金资助项目, No. 05JJ4008
通讯作者: 常小荣, 410007, 湖南省长沙市韶山中路113号, 湖南中医学院针灸推拿学院. xrchang1956@sina.com
电话: 0735-5381163 传真: 0735-5557891
收稿日期: 2006-02-28 接受日期: 2006-03-11
Moxibustion at Zusanli and Liangmen prevents gastric mucosa from oxidation injury through inducing high expression of heat shock protein 70
Xiao-Rong Chang, Na Peng, Shou-Xiang Yi, Yan Peng, Jie Yan
Xiao-Rong Chang, Na Peng, Shou-Xiang Yi, Yan Peng, Jie Yan,College of Acupuncture and Massage, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China.
Supported byNational Natual Science Foundation of China, No. 30572310 and the Natural Science Foundation of Hunan Province, No. 05JJ4008
Correspondence to:Xiao-Rong Chang, College of Acupuncture and Massage, Hunan University of Traditional Chinese Medicine, 113 Shaoshan Middle Road, Changsha 410007, Hunan Province, China. xrchang1956@sina.com
Received:2006-02-28 Accepted:2006-03-11
Abstract
AIM: To observe the effects of moxibustion at Zusanli and Liangmen on the expression of heat shock protein 70 (HSP70) in gastric mucosa in rats with stress-induced ulcer (SU), and explore the mechanism of moxibustion at the acupoints of Foot-Yangming meridian in preventing gastric mucosa from oxidative injury.
METHODS: A total of 60 Sprague Dawley rats were randomly averagely divided into blank group, model group, Zusanli and Liangmen moxibustion group and non-moxibustion control group. After 7 days of pretreatment, the rats, except those in blank group, received water restraint stress (WRS) to induce stress ulcer. The gastric mucosal blood flow (GMBF) was measured by Laser Doppler Flowmetry (LDF) and the ulcer index (UI) was evaluated by Guth method. HSP70 expression and malondialdehyde (MDA) content in gastric mucosa were determined by immunohistochemical and thiobarbiturate technique ......
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