高强度聚焦超声治疗肝细胞癌的疗效及其影响因素
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薛 净, 沙卫红, 聂玉强, 李瑜元, 张亚历,
高强度聚焦超声;肝细胞癌;TNM分期;甲胎蛋白;肝动脉化疗栓塞术;疗效,薛净,沙卫红,聂玉强,李瑜元,张亚历,周殿元,薛净,通讯作者:,E
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薛净, 北京武警医院 北京市 100039
沙卫红, 聂玉强, 李瑜元, 广州医学院附属第一人民医院消化内科 广东省广州市 510180
张亚历, 周殿元, 广州市南方医院消化病研究所 广东省广州市 510515
薛净, 博士后, 主要从事消化系统疾病的基础与临床研究.
通讯作者: 张亚历, 510515, 广东省广州市, 南方医院消化病研究所. zhangyl@fimmu.com
收稿日期: 2006-09-28 接受日期: 2006-10-11
Efficacy of high intensity focused ultrasound in treatment of hepatocellular carcinoma and its influential factors
Jing Xue, Wei-Hong Sha, Yu-Qiang Nie, Yu-Yuan Li, Ya-Li Zhang, Dian-Yuan Zhou
Jing Xue,Beijing Hospital of Chinese PLA Armed Forces, Beijing100039, China
Wei-Hong Sha, Yu-Qiang Nie, Yu-Yuan Li,Department of Gastroenterology, the First Affiliated People Hospital of Guangzhou Medical College, Guangzhou 510180, Guangdong Province, China
Ya-Li Zhang, Dian-Yuan Zhou,Institute of Gastroenterology, Nanfang Hospital, Guangzhou 510515, Guangdong Province, China
Correspondence to:Ya-Li Zhang, Institute of Gastroenterology, Nanfang Hospital, Guangzhou 510515, Guangdong Province, China. zhangyl@fimmu.com
Received:2006-09-28 Accepted:2006-10-11
Abstract
AIM: To observe the efficacy of high intensity focused ultrasound (HIFU) in the treatment of hepatocellular carcinoma (HCC) and investigate the prognostic factors affecting the overall survival.
METHODS: A total of 104 patients with HCC were treated with HIFU and the efficacy was evaluated by the following indexes: tumor size, number, metastasis, alpha fetoprotein (AFP) levels before and after HIFU treatment, hepatic function before HIFU treatment, Child Pugh classifications, TNM stages and variations in color Doppler sonography.
RESULTS: After HIFU treatment, the remission rates for clinical symptoms and liver function were 83.2% (80/104) and 82.7% (86/104), respectively, and the patients with AFP decreased by more than 50% covered a percentage of 62.5% (65/104). After HIFU, color Doppler sonography manifested coagulative necrosis and tumor blood supply reduction or disappearance in the target region ......
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