原发性胆囊癌组织中脆性组氨酸三联体基因和Ki-67的表达及临床意义
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刘会春, 吴斌全
胆囊肿瘤;脆性组氨酸三联体基因;Ki-67抗原;免疫组织化学,刘会春,吴斌全,刘会春,通讯作者:,Expressionoff
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刘会春, 吴斌全, 蚌埠医学院附属医院肝胆外科 安徽省蚌埠市 233004
刘会春, 1984年蚌埠医学院学士, 主任医师, 副教授, 主要从事肝胆胰疾病的临床与基础研究.
通讯作者: 刘会春, 233004, 安徽省蚌埠市长淮路287号, 蚌埠医学院附属医院肝胆外科. doctorlhc2000@yahoo.com.cn
电话: 0552-3060946 传真: 0552-3070260
收稿日期: 2006-03-24 接受日期: 2006-04-20
Expression of fragile histidine triad and Ki-67 in primary gallbladder carcinoma and their clinical significances
Hui-Chun Liu, Bin-Quan Wu
Hui-Chun Liu, Bin-Quan Wu,Department of Hepatobiliary Surgery, the Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China
Correspondence to:Dr. Hui-Chun Liu, Department of Hepatobiliary Surgery, the Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu 233004, Anhui Province, China. doctorlhc2000@yahoo.com.cn
Received:2006-03-24 Accepted:2006-04-20
Abstract
AIM: To investigate the expression of fragile histidine triad (FHIT) gene and Ki-67 antigen in primary gallbladder carcinoma, gallbladder adenoma and chronic cholecystitis.
METHODS: Streptavidin-peroxidase immunohistochemical method was used to determine the expression of FHIT and Ki-67 in 51 cases of primary gallbladder carcinoma, 15 cases of gallbladder adenoma and 12 cases of chronic cholecystitis. Their relationships with clinical and pathological features of gallbladder carcinoma were analyzed.
RESULTS: The positive rate of FHIT expression was significantly lower in gallbladder carcinoma than that in gallbladder adenoma and chronic cholecystitis (47.1% vs 66.7%, 91.7%, P < 0.01), while the positive rate of Ki-67 expression was markedly higher than that in gallbladder adenoma and chronic cholecystitis (82.4% vs 20.0%, 0, P < 0.01). Loss of FHIT expression was significantly correlated with the higher histological grade (18.8% vs 56.5%, 66.7%, P = 0.02) and lymph node or distant metastasis (33.3% vs 66.7%, P = 0.019), as well as survival time after operation (31 ......
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