LMP2/LMP7基因编码区多态性及单倍体型与胃癌易感无相关性
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曹邦伟, 戴 悦, 盖郁慧, 柴庆波, 汪 欣
低分子量蛋白酶体;胃癌;单倍体型;易感,曹邦伟,戴悦,盖郁慧,柴庆波,汪欣,曹邦伟,通讯作者:,电话:, 传真:,收稿日期:,接受日期:,NoassociationbetweenLMP2,LMP7gen
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曹邦伟, 北京大学第一医院抗感染病房, 北京大学临床药理研究所 北京市 100034
戴悦, 盖郁慧, 柴庆波, 北京大学第一医院输血科 北京市 100034
汪欣, 北京大学第一医院普外科 北京市 100034
曹邦伟, 2005年北京大学医学部博士, 主要从事分子遗传学的研究.
通讯作者: 汪欣, 100034, 北京市西城区大红罗厂街1号, 北京大学第一医院普外科. wangxinbeida@126.com
电话: 010-66123261 传真: 010-66123261
收稿日期: 2006-09-19 接受日期: 2006-11-10
No association between LMP2/LMP7 gene polymorphisms or haplotypes and gastric cancer
Bang-Wei Cao, Yue Dai, Yu-Hui Gai, Qing-Bo Chai, Xin Wang
Bang-Wei Cao, Department of Anti-infection; Institute of Clinical Pharmacology, the First Hospital of Peking University, Beijing 100034, China
Yue Dai, Yu-Hui Gai, Qing-Bo Chai, Department of Blood Transfusion, the First Hospital of Peking University, Beijing 100034, China
Xin Wang, Department of General Surgery, the First Hospital of Peking University, Beijing 100034, China
Correspondence to: Xin Wang, Department of General Surgery, the First Hospital of Peking University, 1 Dahongluochang Street, Western District, Beijing 100034,China. wangxinbeida@126.com
Received: 2006-09-19 Accepted: 2006-11-10
Abstract
AIM:To elucidate whether LMP2/LMP7 poly-morphisms or haplotypes were associated with the occurrence of gastric cancer in Han Chinese.
METHODS:The genome DNA was extracted from the peripheral blood of 145 gastric cancer patients and 152 cancer-free controls, and the LMP2-codon60/LMP7-codon145 genotypes were detected by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). The software PHASE1.0 was used to construct the haplotypes of each individual. The unconditional Logistic regression model was applied to analyze the statistical differences of genotypes or haplotypes between the two groups.
RESULTS: PCR-RFLP showed that the polymorphisms were found at both codon60 and codon145 loci of LMP2/LMP7 gene in 297 Chinese individuals, and chi-square test demonstrate that the distributions of LMP2/LMP7 genotypes were in Hardy-Weinberg equilibrium ......
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