摘要:目的 探讨荧光定量聚合酶链反应(FQ-PCR)用于评价阿奇霉素治疗儿童弓形虫(TOX)病的效果。方法 采用FQ-PCR技术，对有弓形虫病临床表现者，检测血TOX-DNA，在阳性者22例中，先天性感染12例，获得性感染10例。所有病例均用阿奇霉素在治疗2个疗程和4个疗程后，分别观察其治疗效果。 结果 全部患儿均有效，病情逐步好转。先天感染组治疗前患儿血TOX-DNA含量(6.21±1.17)copies/ml，治疗2个疗程后TOX-DNA含量(5.46±1.25)copies/ml(P>0.05)，4个疗程后TOX-DNA含量(4.12±1.09)copies/ml(P<0.01);获得性感染组治疗前患儿血TOX-DNA含量(6.79±1.05)copies/ml，治疗2个疗程后TOX-DNA含量(6.09±1.04)copies/ml(P>0.01)，4个疗程后TOX-DNA含量(4.06±0.95)copies/ml(P<0.01)。 结论 22例弓形虫感染患儿服用阿奇霉素治疗，效果显著，未见明显毒副作用，患儿依从性好。

    关键词:弓形虫病;阿奇霉素;聚合酶链反应;幼儿

    Observation on the therapeutic effect of azithromycin on infant toxoplasmosis patients by fluorescence quantitative poly-merase chain reaction.

    FENG Xiao-wei，CHEN Yu-wen，SUN Song，et al.

    (Department of Pediatrics of Hainan Provincial Peo-ple's Hospital，Haikou570311，Hainan，P.R.China)

    Abstract:Objective To evaluate the therapeutic effect of azithromycin on infant toxoplasmosis patients by using fluorescence quantitative polymerase chain reaction(FQ-PCR). Methods The22infants positives for toxoplasma DNA(TOX DNA)and with clinical manifestations including12congenital infection and10acquired infection were detected with FQ-PCR.Azithromycin was given to all the patients with a dose of10mg/kg·d for a course of6days.The therapeutic effect was observed at the end of2courses and4courses respectively. Results The condition of all patients was improved.The contents of TOX DNA in congenital infection group was6.21±1.17copies/ml and5.46±1.25copies/ml respectively before treatment and2courses after treatment ......