食用白酒灌胃后大鼠胃黏膜的抗损伤作用
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秦咏梅, 周 力, 孙屹峰, 张永宏, 侯玉龙, 张国林
食用白酒;胃黏膜;适应性保护;前列腺素E2;转化生长因子α,秦咏梅,孙屹峰,侯玉龙,张国林,周力,张永宏,秦咏梅,通讯作者:,Adaptivecytoprotectionofgastricmucosainratsafterintragastricad
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秦咏梅, 孙屹峰, 侯玉龙, 张国林, 新乡医学院第一附属医院消化内科 河南省新乡市 453100
周力, 张永宏, 贵阳医学院附属医院消化内科 贵州省贵阳市 555000
秦咏梅, 2006年贵阳医学院硕士, 副主任医师, 主要从事消化系统疾病的临床研究.
通讯作者: 秦咏梅, 453100, 河南省新乡市, 新乡医学院第一附属医院消化内科. yongmeiqin120@126.com
收稿日期: 2006-09-30 接受日期: 2006-10-25
Adaptive cytoprotection of gastric mucosa in rats after intragastric administration of edible alcohol
Yong-Mei Qin, Li Zhou, Yi-Feng Sun, Yong-Hong Zhang, Yu-Long Hou, Guo-Lin Zhang
Yong-Mei Qin, Yi-Feng Sun, Yu-Long Hou, Guo-Lin Zhang,Department of Gastroenterology, the Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, He’nan Province, China
Li Zhou, Yong-Hong Zhang,Department of Gastroenterology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou Province, China
Correspondence to:Yong-Mei Qin, Department of Gastroenterology, the Affiliated Hospital of Xinxiang Medical College, Xinxiang 453100, He’nan Province, China. yongmeiqin120@126.com
Received:2006-09-30 Accepted:2006-10-25
Abstract
AIM: To observe the response to edible alcohol-induced injury and expression of prostaglandin E2 (PGE2), transforming growth factor-α (TGF-α) in gastric mucosa of rats.
METHODS: A total of 36 Sprague Dawley rats were divided group A, B, and C, intragastrically treated with edible alcohol (530 ± 20 mL/L), ethanol (530 mL/L), and normal saline at 5 mL/kg once every other day, respectively. The rats were killed at 1 week and 1 month after treatment, and the extent of mucosal injury was evaluated. Immunohistochemistry was used to examine the mucosal expression of TGF-α protein. Anther 36 rats were selected and treated as the method mentioned above, and the level of PGE2 in gastric mucosa was determined by enzyme linked immunosorbent assay.
RESULTS: The most severe gastric mucosal injury was found in group C, then in group B, and the rats in group A were found with the mildest mucosal injury ......
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