番石榴叶提取物对三硝基苯磺酸诱导大鼠结肠炎结肠组织的保护作用
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廖泽云, 李玉山, 姜锦林
番石榴叶提取物;抗氧化作用;调节免疫;结肠炎;大鼠,廖泽云,李玉山,姜锦林,通讯作者:,Protectiveeffectofguavaleafextractoncolonictissueswithulcerativecolonit
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廖泽云, 李玉山, 湖北民族学院医学院生理学教研室 湖北省恩施市 445000
姜锦林, 湖北民族学院附属医院 湖北省恩施市 445000
通讯作者: 廖泽云, 445000, 湖北省恩施市, 湖北民族学院医学院. lzy121192004@126.com
电话: 0718-8235239
收稿日期: 2006-06-05 接受日期: 2006-06-30
Protective effect of guava leaf extract on colonic tissues with ulcerative colonitis induced by trinitrobenzene sulfonic acid in rats
Ze-Yun Liao, Yu-Shan Li, Jin-Lin Jiang
Ze-Yun Liao, Yu-Shan Li,Department of Physiology, Medical College of Hubei Institute for Nationalities, Enshi 44500, Hubei Province, China
Jin-Lin Jiang,the Affiliated Hospital of Medical College of Hubei Institute for Nationalities, Enshi 445000, Hubei Province, China
Correspondence to:Ze-Yun Liao, Department of Physiology, Medical College of Hubei Institute for Nationalities, Enshi 44500, Hubei Province, China. lzy121192004@126.com
Received:2006-06-05 Accepted:2006-06-30
Abstract
AIM: To explore the protective effect of guava leaf water extract on the colonic tissues with ulcerative colonitis induced by trinitrobenzene sulfonic acid (TNBS) as well as its mechanism in rats.
METHODS: Rat model of ulcerative colonitis was established by clyster of TNBS. After treatment with guava leaf extract for 2 weeks, the colon mucosal damage index (CMDI) was evaluated. The activity of myeloperoxidase (MPO), superoxide dismutase (SOD), the content of malondialdehyde (MDA) in colon tissues, and the levels of tumor necrosis factor (TNF), interleukin-8 (IL-8) and interleukin-10 (IL-10) in serum were examined.
RESULTS: Guava leaf extract (200, 500, 800 mg/kg) decreased the values of CMDI (2 ......
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