血红素氧合酶的干预对糖尿病大鼠结肠动力障碍的影响
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吴高珏, 林 琳, 张红杰, 李学良, 罗 云, 王美峰
血红素氧合酶;糖尿病;结肠动力障碍;正铁血红素;锌原卟啉,吴高珏,林琳,张红杰,李学良,罗云,王美峰,吴高珏,通讯作者:,Effectofinterferenceinhemeoxygenaseoncolonicdysfunctionofdia
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吴高珏, 林琳, 张红杰, 李学良, 罗云, 王美峰, 南京医科大学第一附属医院消化科 江苏省南京市 210029
吴高珏, 南京医科大学硕士研究生在读, 主要从事胃肠动力性疾病方面的研究.
江苏省“135工程”医学重点人才基金项目, No. 苏卫科教[2003]19号
江苏省自然科学基金项目, No. BK2004158
通讯作者: 林琳, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院消化科. lin9100@yahoo.com.cn
电话: 025-83718836-6920
收稿日期: 2006-10-10 接受日期: 2006-11-02
Effect of interference in heme oxygenase on colonic dysfunction of diabetic rats
Gao-Jue Wu, Lin Lin, Hong-Jie Zhang, Xue-Liang Li, Yun Luo, Mei-Feng Wang
Gao-Jue Wu, Lin Lin, Hong-Jie Zhang, Xue-Liang Li, Yun Luo, Mei-Feng Wang,Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported bythe Fund from “135 Project” for the Key Talents of Health and Science Education Department of Jiangsu Province, No[2003]19, and the Natural Science Foundation of Jiangsu Province, No. BK2004158
Correspondence to:Dr. Lin Lin, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. lin9100@yahoo.com.cn
Received:2006-10-10 Accepted:2006-11-02
Abstract
AIM: To investigate the effect of heme oxygenase (HO) interference on the colonic dysfunction in rats with diabetes mellitus (DM).
METHODS: DM model was established by intraperitoneal injection of streptozotocin (STZ) in Sprague and Dawley rats. Six weeks later, the diabetic rats were validated to be suffered with gastrointestinal dysfunction using charcoal (Indian ink) propulsion experiment. Then the rest rats were randomly divided into 4 groups, named group A (normal control), B (diabetic rats without interference), C (diabetic rats administrated with Hemin, the inducer of HO) and D [diabetic rats administrated with zinc protoporphyrin Ⅸ (ZnPP Ⅸ), the inhibitor of HO]. The weight and blood glucose of the rats were tested ......
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