结肠途径治疗对高温中暑狗肝脏的保护作用
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姚 欣, 冯子坛, 白启轩, 吉 丽, 贾 昭, 吴 颖, 刘文格, 孙 蓉
结肠途径治疗;狗;高温;肝脏疾病,姚欣,冯子坛,白启轩,吉丽,贾昭,吴颖,刘文格,孙蓉,通讯作者:,收稿日期:,接受日期:,Effectsofcolonhydrotherapyonliverinjuryinducedbyhyperthermiaindog
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姚欣, 冯子坛, 白启轩, 吉丽, 贾昭, 吴颖, 刘文格, 孙蓉, 白求恩国际和平医院消化内科 河北省石家庄市 050082
通讯作者: 姚欣, 050082, 河北省石家庄市中山西路398号, 白求恩国际和平医院消化内科. xinyaoyongpeng@126.com
收稿日期: 2006-09-24 接受日期: 2006-10-26
Effects of colon hydrotherapy on liver injury induced by hyperthermia in dogs
Xin Yao, Zi-Tan Feng, Qi-Xuan Bai, Li Ji, Zhao Jia, Ying Wu, Wen-Ge Liu, Rong Sun
Xin Yao, Zi-Tan Feng, Qi-Xuan Bai, Li Ji, Zhao Jia, Ying Wu, Wen-Ge Liu, Rong Sun,Department of Gastroenterology, Bethune International Peace Hospital, Shijiazhuang 050082, Hebei Province, China
Correspondence to:Xin Yao, Department of Gastroenterology, Bethune International Peace Hospital, 398 Zhongshan West Road, Shijiazhuang 050082, Hebei Province, China. xinyaoyongpeng@126.com
Received:2006-09-24 Accepted:2006-10-26
Abstract
AIM: To investigate the effect of colon hydrothe-rapy on the liver injury induced by hyperthermia in dogs.
METHODS: After the dog models of heat stroke were set up, the dogs were randomly divided into two groups, receiving colon hydrotherapy and conventional therapy, respectively. Cooling time as well as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxide dismutase (SOD) levels before heat stroke, 6, 24 and 48 h after heat stroke were determined. The dogs were sacrificed 48 h after heat stroke. The contents of liver MDA and SOD were also measured and pathological changes were observed by light and electron microscopy.
RESULTS: In compared with those in conventional therapy group, the cooling time of dogs in colon hydrotherapy group was decreased (t = 5.39, P < 0.01), accompanied with reduced ALT, AST, MDA and elevated SOD at the 24th (t = 3.46, P < 0.01;t = 3.74, P < 0.01; t = 2.43, P < 0.05; t = 2.44, P < 0.05) and 48th (t = 3.33, P < 0.01; t = 2.97, P < 0 ......
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