糖尿病与结直肠癌患病危险关系的调查分析
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胡水清, 汤 哲, 张 玫
结直肠癌;糖尿病;流行病学;危险因素,胡水清,汤哲,张玫,通讯作者:,Investigationontherisksofcolorectalcancerinpatientswithdiabetesmellitus,Shui-QingHu,ZheTang
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胡水清, 汤哲, 张玫, 首都医科大学宣武医院消化内科 北京市 100053
通讯作者: 胡水清, 100053, 北京宣武区长椿街45号, 首都医科大学宣武医院消化内科. wangrongxin@sina.com
电话: 010-83198899-8860
收稿日期: 2006-10-13 接受日期: 2006-11-04
Investigation on the risks of colorectal cancer in patients with diabetes mellitus
Shui-Qing Hu, Zhe Tang, Mei Zhang
Shui-Qing Hu, Zhe Tang, Mei Zhang,Department of Gastroenterology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
Correspondence to: Shui-Qing Hu,Department of Gastroenterology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China. wangrongxin@sina.com
Received:2006-10-13 Accepted:2006-11-04
Abstract
AIM: To investigate the influences of DM-associated factors on the pathogenesis of colorectal cancer (CRC), and clarify whether diabetes mellitus (DM) is a risk factor of CRC.
METHODS: A case-control study was performed to compare 364 colorectal cancer patients (198 colon cancer patients and 166 rectal cancer patients) with 733 controls (patients without cancer), with respect to their family history of CRC and DM, personal DM history, habits of smoking and drinking, cholesterol and triglyceride levels.
RESULTS: The value of odds ratio (OR) in patients with DM history was 1.72 and that in patients with family DM history was 1.64. The value of OR in DM patients with family CRC history was 3.23, significantly higher in DM patients without family CRC history (OR = 1.57). After further analysis, the rate of DM patients with/without family CRC history was always higher than that in the controls. Logistic analysis showed that the age, gender, DM history, coronary heart disease, hypertension, smoking, drinking, and blood lipid had no marked relationship with colorectal cancer, but DM and family CRC history were correlated with the occurrence of colorectal cancer (OR = 2 ......
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