热休克蛋白90β；糖皮质激素类；突变_

HSP90β基因突变与糖皮质激素治疗敏感性的关系

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热休克蛋白90β；糖皮质激素类；突变,,热休克蛋白90β；糖皮质激素类；突变,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Relationship between HSP90β gene mutation and glucocorticoid therapy sensitivity

    ZHAO Yan, WANG Hua, CHEN XingYun, JI YeWei, ZHOU YuanGuo

    Center of Molecular Biology, Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China

    【Abstract】 AIM: To screen the mutation of heat shock protein 90β(HSP90β) gene in patients with primary nephrotic syndrome and to investigate the association between the mutation and the sensitivity to glucocorticoid therapy. METHODS: Extract the blood DNA of the 300 glucocoiticoidtreated primary nephrotic syndrome patients. PCR approach was used to amplify intron 9, exon10, intron 10, exon11 and 3 untranslated region of HSP90β, and automated fluorescent sequencing technology was applied to detect the mutation of the region. RESULTS: Two point mutations of HSP90β, 7489 C>T in intron 10 and 7612 C>T in 3 untranslated region were found in primary nephrotic syndrome patients. The mutation frequency of glucocoiticoidsensitive and glucocoiticoidresisted patients were 2.44% ......

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